Coagulation disorders in pregnancy: acquired and inherited thrombophilias
Coagulation disorders in pregnancy: acquired and inherited thrombophilias
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DOI：
10.1111/j.1749-6632.2010.05674.x
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Di Giampaolo, Francesca
中科院分区：
文献类型：
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作者：
Benedetto, Chiara;Marozio, Luca;Di Giampaolo, Francesca
获得性和遗传性血栓形成倾向均与妊娠相关静脉血栓栓塞 (VTE) 风险增加以及不良妊娠结局相关。然而，每种血栓形成倾向和结果的归因风险的延伸仍然是一个有争议的问题。血栓形成倾向与 VTE 和妊娠并发症有关，例如：复发性和非复发性早期妊娠流产、晚期胎儿死亡、胎盘早剥、胎儿生长受限和先兆子痫。本综述讨论了血栓形成倾向与妊娠结局之间关联的证据以及临床管理和预防策略的问题。
Both acquired and inherited thrombophilias are associated with an increased risk of pregnancy-related venous thromboembolism (VTE) as well as with adverse pregnancy outcome. However, the extension of attributable risk for each thrombophilia and outcome is still a question of debate. Thrombophilias have been investigated in connection with VTE and pregnancy complications such as: recurrent and nonrecurrent early pregnancy loss, late fetal death, placental abruption, fetal growth restriction, and preeclampsia. This review discusses the evidence of association between thrombophilias and pregnancy outcome together with issues as to clinical management and preventive strategies.