Roles of the BAP1 Tumor Suppressor in Cell Metabolism.
Roles of the BAP1 Tumor Suppressor in Cell Metabolism.
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DOI：
10.1158/0008-5472.can-20-3430
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发表时间：
2021-06-01
期刊：
影响因子：
11.2
通讯作者：
Aplin AE
中科院分区：
文献类型：
--
作者：
Han A;Purwin TJ;Aplin AE
BRCA1相关蛋白1(BAP1)是目前研究较多的肿瘤相关基因。BAP1的种系突变会导致癌症综合征，在几种癌症类型中都会发现体细胞缺失。BAP1编码一种脱泛素酶，在细胞周期调节、细胞死亡和分化中起关键作用。最近的研究表明，BAP1还参与了细胞代谢的多个方面，包括代谢平衡、葡萄糖利用、铁性下垂的控制和应激反应。更好地了解癌症相关基因的代谢作用对于了解肿瘤的发生和发展以及强调潜在的治疗途径是重要的。通过这篇综述，我们总结了目前关于BAP1介导的代谢活动调节的知识，这些知识可能支持治疗BAP1突变癌症的新策略。
BRCA1-associated protein 1 (BAP1) is emerging as an intensively studied cancer-associated gene. Germline mutations in BAP1 lead to a cancer syndrome, and somatic loss is found in several cancer types. BAP1 encodes a deubiquitinase enzyme, which plays key roles in cell cycle regulation, cell death, and differentiation. Recent studies have demonstrated that BAP1 is also involved in several aspects of cellular metabolism, including metabolic homeostasis, glucose utilization, control of ferroptosis, and stress response. A better knowledge of the metabolic roles of cancer-associated genes is important to understanding tumor initiation and progression, as well as highlighting potential therapeutic avenues. With this review, we summarize the current knowledge regarding BAP1-mediated regulation of metabolic activities that may support new strategies to treat BAP1-mutated cancers.