A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models
A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models
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DOI：
10.1016/s0169-2607(98)00098-4
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发表时间：
1999-04-01
影响因子：
6.1
通讯作者：
Charles, BG
中科院分区：
文献类型：
--
作者：
Parke, J;Holford, NHG;Charles, BG
介绍了一种方法，用于自助数据样本的自动化制备及其呈现给NONMEM，用于验证群体药代动力学或药效学模型，这些模型是用相对较少的受试者开发的。引导抽样程序涉及使用MS-DOS批处理文件和脚本文件，用于公共域文本处理程序AWK，该脚本文件是单个EXE文件（本报告中使用的版本大小为48 k）。还提供了AWK的UNIX版本，UNIX用户可以根据自己的需要调整流程。它的使用消除了对昂贵的高端统计软件包和使用内置编程语言编写的相关脚本文件的需要。该方法可以很容易地适应其他生物医学建模应用中的自举采样要求。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
A method is presented for automated preparation of bootstrap data samples and their presentation to NONMEM for use in the validation of population pharmacokinetic or pharmacodynamic models, which have been developed with relatively small numbers of subjects. The bootstrap sampling procedure involves the use of an MS-DOS batch file and a script file for use with the public-domain text processing program, AWK, which is a single EXE file (48k in size for the version used in this report). A UNIX version of AWK is also available and UNIX users can adapt the process to their needs. Its use obviates the need for expensive, high-end statistical packages and associated script files written using in-built programming languages. The method can easily be adapted to bootstrap sampling requirements in other biomedical modelling applications. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.