Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11-14 weeks' gestation
Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11-14 weeks' gestation
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DOI：
10.1002/uog.3881
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发表时间：
2007-02-01
影响因子：
7.1
通讯作者：
Antsaklis, A.
中科院分区：
文献类型：
--
作者：
Pilalis, A.;Souka, A. P.;Antsaklis, A.
目的：探讨孕妇人口学特征、子宫动脉血流速度测定、孕妇血清妊娠相关血浆蛋白-A(PAPP-A)及其联合检测在筛查11~14周子痫前期和小于胎龄儿中的作用。方法：对878例妊娠11~14周孕妇进行前瞻性研究。应用脉冲多普勒技术获得子宫动脉血流速度波形，计算子宫动脉平均搏动指数(PI)。检测孕妇血清中PAPP-A的含量。与母体病史一起，比较这些测量方法预测不良结局的能力，定义为先兆子痫和/或胎盘早剥。结果：平均子宫动脉PI>；=95百分位数和PAPP-A
Objective: To assess the role of maternal demographic characteristics, uterine artery Doppler velocimetry, maternal serum pregnancy-associated plasma protein-A (PAPP-A) and their combination in screening or pre-eclampsia and small-for-gestational age (SGA) fetuses at 11-14 weeks.Methods: This was a prospective study of 878 consecutive women presenting for a routine prenatal ultrasound examination at 11-14 weeks. Pulsed wave Doppler was then used to obtain uterine artery flow velocity waveforms and the mean pulsatility index (PI) of the uterine arteries was calculated. Maternal serum samples for PAPP-A were assayed. Along with maternal history, these measurements were compared in their ability to predict adverse outcome, defined as pre-eclampsia and/or SGA and/or placental abruption.Results: Mean uterine artery PI >= 95(th) centile and PAPP-A