Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models.
Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models.
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DOI：
10.1016/j.jbiomech.2014.01.010
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发表时间：
2014-03-03
影响因子：
2.4
通讯作者：
Weinbaum, Sheldon
中科院分区：
文献类型：
--
作者：
Cardoso, Luis;Kelly-Arnold, Adreanne;Maldonado, Natalia;Laudier, Damien;Weinbaum, Sheldon
大约一半与急性冠状动脉综合征相关的心血管死亡发生在冠状动脉血管中坏死核心上覆盖的薄纤维帽组织在高血压的作用下撕裂、撕裂或裂开时。从生物力学的角度来看，动脉粥样硬化的破裂是由于病变中机械应力的增加，其中超过了组织的极限应力（即，失效时的峰值周向应力（PCS））。包括帽厚度、形态学、残余应力和动脉粥样硬化的组织成分在内的几个因素已被证明会影响PCS。同样重要的是，我们最近证明了> 5 µm的微钙化（µCalcs）是人类动脉粥样硬化帽的常见特征，其表现为局部应力集中，使局部组织应力增加至少两倍，超过帽组织破裂的极限应力阈值。在本研究中，我们使用了理想化的球形µCalcs和来自人类冠状动脉粥样硬化帽的实际µCalcs，以确定它们对使用不同超弹性本构模型增加纤维粥样硬化帽中的周向应力的影响。我们发现，纤维粥样硬化帽中µCalcs产生的应力集中系数（SCF）受材料组织特性、µCalcs间距、纵横比及其相对于帽拉伸轴的对齐情况的影响。
Approximately half of all cardiovascular deaths associated with acute coronary syndrome occur when the thin fibrous cap tissue overlying the necrotic core in a coronary vessel is torn, ripped or fissured under the action of high blood pressure. From a biomechanics point of view, the rupture of an atheroma is due to increased mechanical stresses in the lesion, in which the ultimate stress (i.e. peak circumferential stress (PCS) at failure) of the tissue is exceeded. Several factors including the cap thickness, morphology, residual stresses and tissue composition of the atheroma have been shown to affect the PCS. Also important, we recently demonstrated that microcalcifications (µCalcs) > 5 µm are a common feature in human atheroma caps, which behave as local stress concentrators, increasing the local tissue stress by at least a factor of two surpassing the ultimate stress threshold for cap tissue rupture. In the present study, we used both idealized µCalcs with spherical shape and actual µCalcs from human coronary atherosclerotic caps, to determine their effect on increasing the circumferential stress in the fibroatheroma cap using different hyperelastic constitutive models. We have found that the stress concentration factor (SCF) produced by µCalcs in the fibroatheroma cap is affected by the material tissue properties, µCalcs spacing, aspect ratio and their alignment relative to the tensile axis of the cap.
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影响因子：
6.2
作者：
Palacio-Mancheno, Paolo E.;Larriera, Adriana I.;Doty, Stephen B.;Cardoso, Luis;Fritton, Susannah P.
通讯作者：
Fritton, Susannah P.
影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
影响因子：
2.2
作者：
Belzacq, Tristan;Avril, Stephane;Delache, Alexandre
通讯作者：
Delache, Alexandre
DOI：
10.1016/s0735-1097(02)02047-8
发表时间：
2002-09-04
影响因子：
24
作者：
Maehara, A;Mintz, GS;Weissman, NJ
通讯作者：
Weissman, NJ
影响因子：
3.8
作者：
Vengrenyuk, Yuliya;Kaplan, Theodore J.;Weinbaum, Sheldon
通讯作者：
Weinbaum, Sheldon