Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity
Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity
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DOI：
10.3892/etm.2020.8950
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发表时间：
2020-09-01
影响因子：
2.7
通讯作者：
Wu, Bin
中科院分区：
文献类型：
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作者：
Peng, Liping;Zhu, Ning;Wu, Bin
本研究旨在探讨C-X-C基序趋化因子受体4 （CXCR4）和CXC配体12 （CXCL12）在类风湿关节炎（RA）患者中的表达水平及其与疾病活动度的相关性。共选择60例RA患者作为研究组，其中活动期28例，缓解期32例。同时选取60例骨性关节炎患者作为对照组。Western blotting和ELISA分别检测CXCR4和CXCL12的表达。采用Spearman相关检验分析CXCR4、CXCL12与红细胞沉降率（ESR）、c反应蛋白（CRP）、疾病活动性评分28 （DAS28）、类风湿因子（RF）的相关性。本研究结果提示，研究组血清和关节滑液中CXCR4和CXCL12的表达水平明显高于对照组(P
The present study aimed to investigate the expression levels of C-X-C motif chemokine receptor 4 (CXCR4) and CXC ligand 12 (CXCL12) in patients with rheumatoid arthritis (RA) and the correlation with disease activity. In total, 60 patients with RA were selected as the study group, comprising of 28 patients in active-stage and 32 patients in remission-stage. In addition, 60 patients with osteoarthritis were selected as the control group. Western blotting and ELISA were used to detect the expression of CXCR4 and CXCL12, respectively. The Spearman's correlation test was used to analyze correlations between CXCR4 and CXCL12, and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score 28 (DAS28) scores and rheumatoid factor (RF). The present results suggested that CXCR4 and CXCL12 expression levels in the serum and joint synovial fluid of the study group were significantly higher compared with the control group (P