Bioactive Maleic Anhydrides and Related Diacids from the Aquatic Hyphomycete Tricladium castaneicola
Bioactive Maleic Anhydrides and Related Diacids from the Aquatic Hyphomycete Tricladium castaneicola
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来自水生丝菌 Tricladium castaneicola 的生物活性马来酸酐和相关二酸
DOI：
10.1021/np500773s
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发表时间：
2015
期刊：
影响因子：
5.1
通讯作者：
and Makoto Ojika
中科院分区：
文献类型：
--
作者：
Chunguang Han;Hiroyuki Furukawa;Tomohiko Tomura;Ryosuke Fudou;Kenichi Kaida;Bong-Keun Choi;Genji Imokawa;and Makoto Ojika
从水生丝孢菌赤霉病（Tricladium castaneicola）中分离得到4个马来酸酐衍生物Tricladolides A-D（1-4）和3个亚烷基琥珀酸衍生物Tricladic Acids A-C（5-7）。所有化合物的结构均经波谱分析确定，均为新化合物。这些化合物对真菌，特别是Phytophthorasp.，卵菌纲的植物病原体。这些代谢产物的抑制活性揭示了环酐结构和亲脂性的烷基侧链的重要性。另一方面，化合物对B16黑色素瘤细胞的细胞毒性表明环酐结构不是必需的。
Four maleic anhydride derivatives, tricladolides A–D (1–4), and three alkylidene succinic acid derivatives, tricladic acids A–C (5–7), were isolated from the aquatic hyphomyceteTricladium castaneicola. The structures of these compounds were determined by spectroscopic analysis, and all were found to be novel. The compounds exhibited inhibitory activity against fungi, particularlyPhytophthorasp., a plant pathogen of oomycetes. The inhibitory activity of these metabolites revealed the importance of the cyclic anhydride structure and the lipophilicity of the alkyl side chain. On the other hand, the cytotoxicity of the compounds against B16 melanoma cells indicated that the cyclic anhydride structure was not essential.