Piezoelectric-driven droplet impact printing with an interchangeable microfluidic cartridge
Piezoelectric-driven droplet impact printing with an interchangeable microfluidic cartridge
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DOI：
10.1063/1.4928298
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发表时间：
2015-09-01
期刊：
影响因子：
3.2
通讯作者：
Pan, Tingrui
中科院分区：
文献类型：
--
作者：
Li, Baoqing;Fan, Jinzhen;Pan, Tingrui
近年来，微流控冲击打印以其简单的设备结构、低成本、无污染、可扩展性和高吞吐量等特点被广泛应用。在本文中，我们介绍了一个基于冲击的液滴打印平台，利用一个简单的即插即用微流体盒由压电驱动器驱动。这种可定制的打印系统允许超细控制液滴体积，从皮升（类似于23pl）到纳升（类似于10nl）， 500倍的变化。除了喷嘴尺寸限制外，还可以通过控制驱动的幅度（例如驱动电压）和驱动脉冲的波形形状来简单地实现液滴生成的高度灵活性。对这些参数进行了详细的打印表征。研制了一种具有单液滴喷射、多液滴喷射和浓度梯度生成功能的多路冲击打印系统。此外，还在该打印平台上进行了通用生物测定测试和验证。因此，微流控液滴打印系统对于建立多路复用微反应器，实现高通量生命科学应用具有潜在价值。(C) 2015 AIP出版有限责任公司
Microfluidic impact printing has been recently introduced, utilizing its nature of simple device architecture, low cost, non-contamination, and scalable multiplexability and high throughput. In this paper, we have introduced an impact-based droplet printing platform utilizing a simple plug-and-play microfluidic cartridge driven by piezoelectric actuators. Such a customizable printing system allows for ultrafine control of droplet volume from picoliters (similar to 23 pl) to nanoliters (similar to 10 nl), a 500 fold variation. The high flexibility of droplet generation can be simply achieved by controlling the magnitude of actuation (e.g., driving voltage) and the waveform shape of actuation pulses, in addition to nozzle size restrictions. Detailed printing characterizations on these parameters have been conducted consecutively. A multiplexed impact printing system has been prototyped and demonstrated to provide the functions of single-droplet jetting and droplet multiplexing as well as concentration gradient generation. Moreover, a generic biological assay has also been tested and validated on this printing platform. Therefore, the microfluidic droplet printing system could be of potential value to establish multiplexed micro reactors for high-throughput life science applications. (C) 2015 AIP Publishing LLC.