FLUORINATED BLOOD SUBSTITUTE RETENTION IN THE RAT MEASURED BY F-19 MAGNETIC-RESONANCE-IMAGING
FLUORINATED BLOOD SUBSTITUTE RETENTION IN THE RAT MEASURED BY F-19 MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1097/00004424-199208000-00012
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发表时间：
1992-08-01
影响因子：
6.7
通讯作者：
JOSEPH, PM
中科院分区：
文献类型：
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作者：
MEYER, KL;CARVLIN, MJ;JOSEPH, PM
理论基础和目标。全氟碳化物(PFC)乳剂已被测试为血液替代品。然而，有证据表明，网状内皮系统(Res)的器官可以长期保留一些PFC。用氟-19(F-19)核磁共振成像(MRI)研究了全氟三丙胺(FTPA)血液代用品在器官中的滞留情况。在注射后86周，用F-19MRI测量肝脏和脾中FTPA的含量。数据符合线性和指数消除模型，并计算了器官保留半衰期。结果：肝脾FTPA的指数半衰期为110~190天。线性半衰期为175~300天。结论：F-19MRI可以定量FTPA在肝和脾中的滞留。测得的半衰期比之前报道的FTPA的半衰期要长。
RATIONALE AND OBJECTIVES. Emulsions of perfluorocarbons (PFCs) have been tested as blood substitutes. However, evidence exists that there is long-term retention of some PFCs by the organs of the reticuloendothelial system (RES). The authors investigate organ retention of the blood substitute component, perfluorotripropylamine (FTPA), using fluorine-19 (F-19) magnetic resonance imaging (MRI).METHODS. Various dosages of an emulsion of FTPA were administered to five rats. At intervals up to 86 weeks after infusion, F-19 MRI was used to measure the amount of FTPA in liver and spleen. The data were fit to both linear and exponential elimination models, and organ retention half-lives were calculated.RESULTS. The exponential half-lives for combined liver and spleen FTPA ranged from 110 to 190 days. Linear half-lives ranged from 175 to 300 days.CONCLUSIONS. FTPA retained by the liver and spleen may be quantified by F-19 MRI. The half-lives that were measured are longer than those reported previously for FTPA.