Change in Bone Density and Reduction in Fracture Risk: A Meta-Regression of Published Trials
Change in Bone Density and Reduction in Fracture Risk: A Meta-Regression of Published Trials
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DOI：
10.1002/jbmr.3641
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发表时间：
2019-04-01
影响因子：
6.2
通讯作者：
Black, Dennis M.
中科院分区：
文献类型：
--
作者：
Bouxsein, Mary L.;Eastell, Richard;Black, Dennis M.
Meta-analyses conducted >15 years ago reported that improvements in bone mineral density (BMD) were associated with reduction in vertebral and nonvertebral fractures in osteoporosis trials. Numerous studies have been conducted since then, incorporating new therapies with different mechanisms of action and enrolling many more subjects. To extend these prior analyses, we conducted a meta-regression of 38 placebo-controlled trials of 19 therapeutic agents to determine the association between improvements in BMD and reductions in fracture risk. We used a linear model to examine the relationship between mean percent difference in BMD change between treatment and placebo groups and the logarithm of the relative risk. We found that greater improvements in BMD were strongly associated with greater reductions in vertebral and hip fractures but not nonvertebral fractures. For vertebral fracture, the r(2) values for total hip, femoral neck, and lumbar spine BMD change were 0.56, 0.54, and 0.63, respectively (p
