Cobalt(II)-based Metalloradical Activation of 2-(Diazomethyl)-pyridines for Radical Transannulation and Cyclopropanation
Cobalt(II)-based Metalloradical Activation of 2-(Diazomethyl)-pyridines for Radical Transannulation and Cyclopropanation
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DOI：
10.1002/anie.201711209
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发表时间：
2018-02-19
影响因子：
16.6
通讯作者：
Chattopadhyay, Buddhadeb
中科院分区：
文献类型：
--
作者：
Roy, Satyajit;Das, Sandip Kumar;Chattopadhyay, Buddhadeb
A new catalytic method for the denitrogenative transannulation/cyclopropanation of in-situ-generated 2-(diazomethyl)pyridines is described using a cobalt-catalyzed radical-activation mechanism. The method takes advantage of the inherent properties of a Co-III-carbene radical intermediate and is the first report of denitrogenative transannulation/cyclopropanation by a radical-activation mechanism, which is supported by various control experiments. The synthetic benefits of the metalloradical approach are showcased with a short total synthesis of (+/-)-monomorine.
