Immunohistochemistry of central respiratory neurotransmitters.
Immunohistochemistry of central respiratory neurotransmitters.
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中枢呼吸神经递质的免疫组织化学。
DOI：
10.1152/ajplung.1991.260.6.l374
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
HoltmanJr,JR
中科院分区：
文献类型：
--
作者：
HoltmanJr,JR
在确定哺乳动物呼吸中枢控制所涉及的细胞核和通路方面已经取得了重大进展。这些知识提供了一个框架，从这个框架中可以集中讨论哪些假定的神经递质可能参与中枢呼吸控制的问题。化学神经解剖学方法的应用，特别是免疫组织化学，是解决这一重要问题的有力方法。这篇评论讨论了免疫组化方法如何被用来扩展我们对中枢呼吸神经递质的认识，以及如何进一步应用它们来获得新的信息。免疫组化研究的结果提供了一个基本原理，随后的生理和药理学研究的呼吸神经元的特定行动的推定的神经递质可以进行评估。
Significant progress has been made in identifying the nuclei and pathways involved in central control of respiration in mammals. This knowledge provides a framework from which to focus on the question of which putative neurotransmitters may be involved in central respiratory control. Application of chemical neuroanatomical methods, particularly immunohistochemistry, is a powerful approach to this important question. This commentary discusses how immunohistochemical approaches have been used so far to extend our knowledge of central respiratory neurotransmitters and also how they can be further applied to gain new information. The results of immunohistochemical studies provide a rationale for subsequent physiological and pharmacological studies of respiratory neurons where specific actions of putative neurotransmitters can be evaluated.