EFFECTS OF 3-AMINO-1,2,4-TRIAZOLE (AT) ON CATALASE AND OTHER COMPOUNDS
EFFECTS OF 3-AMINO-1,2,4-TRIAZOLE (AT) ON CATALASE AND OTHER COMPOUNDS
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DOI：
10.1152/ajplegacy.1956.186.1.19
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发表时间：
1956-01-01
影响因子：
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通讯作者：
PYFROM, HT
中科院分区：
文献类型：
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作者：
HEIM, WG;APPLEMAN, D;PYFROM, HT
大鼠肝脏和肾脏，但不是血液，过氧化氢酶活性下降深刻的前3小时内腹腔内或静脉注射AT后。小鼠口服AT可导致肝脏过氧化氢酶活性降低。单次腹腔注射后约7天，大鼠肝、肾过氧化氢酶活性恢复正常。肝细胞色素C含量、血红蛋白水平和尿胆素原排泄不受AT给药的影响。注射AT后3小时，肝脏过氧化物酶活性略有下降，但在24小时内恢复正常。延长AT给药对幼龄大鼠的生长速率没有影响。AT降低过氧化氢酶活性的植物组织匀浆，肝匀浆和结晶过氧化氢酶在体外，但仅在高浓度。AT在体内引起植物叶绿素含量和过氧化氢酶活性的降低，但对这两种成分的相对作用因物种、生理状态和浓度而异。
Rat liver and kidney, but not blood, catalase activity decreases profoundly within the first 3 hours after the intraperitoneal or intravenous injection of AT. AT given orally to mice causes a reduction of liver catalase activity. Liver and kidney catalase activity of rats returns to normal about 7 days after a single intraperitoneal injection. Liver cytochrome C content, hemoglobin level and urinary urobilinogen excretion are not affected by AT administration. Liver peroxidase activity is decreased slightly 3 hours after injection of AT but returns to normal within 24 hours. Prolonged AT administration has no effect on the growth rate of young rats. AT reduces the catalase activity of plant tissue homogenates, liver homogenates and crystalline catalase in vitro but only at high concentrations. AT causes a reduction of chlorophyll content and catalase activity of plants when given in vivo but the relative effect against these 2 constituents varies with species, physiological state and concentration.