In vivo electrical bioimpedance characterization of human lung tissue during the bronchoscopy procedure. A feasibility study
In vivo electrical bioimpedance characterization of human lung tissue during the bronchoscopy procedure. A feasibility study
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DOI：
10.1016/j.medengphy.2012.09.004
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发表时间：
2013-07-01
影响因子：
2.2
通讯作者：
Bragos, Ramon
中科院分区：
文献类型：
--
作者：
Sanchez, Benjamin;Vandersteen, Gerd;Bragos, Ramon
肺活检是诊断肺癌的基础。然而，在相当数量的病例中，支气管镜肺活检不能提供有用的信息，特别是在弥漫性肺疾病中，因此需要更积极的手术。使用基于多重电阻抗谱（EIS）的引导电子活检可以提高成功率，本文对该技术进行了评估。对测量方法的理论基础和所研制的仪器进行了描述、表征和校准，并通过实验对仪器的性能进行了评估，以评估在幻影上测量产生的噪声和非线性误差来源。附加的初步结果表明，在支气管镜检查过程中监测人体肺组织电生物阻抗（EBI）是可行和安全的。进行支气管镜检查所需的时间不会延长，因为生物阻抗测量在任何被测量的患者中都不会出现并发症、耐受性问题或副作用。(c) 2012 IPEM。Elsevier Ltd.出版。版权所有。
Lung biopsies form the basis for the diagnosis of lung cancer. However, in a significant number of cases bronchoscopic lung biopsies fail to provide useful information, especially in diffuse lung disease, so more aggressive procedures are required. Success could be improved using a guided electronic biopsy based on multisine electrical impedance spectroscopy (EIS), a technique which is evaluated in this paper. The theoretical basis of the measurement method and the instrument developed are described, characterized and calibrated while the performance of the instrument is assessed by experiments to evaluate the noise and nonlinear source of errors from measurements on phantoms. Additional preliminary results are included to demonstrate that it is both feasible and safe to monitor in vivo human lung tissue electrical bioimpedance (EBI) during the bronchoscopy procedure. The time required for performing bronchoscopy is not extended because the bioimpedance measurements, present no complications, tolerance problems or side effects among any of the patients measured. (c) 2012 IPEM. Published by Elsevier Ltd. All rights reserved.