Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes
Increased neurotrophin-3 in drug-free subjects with bipolar disorder during manic and depressive episodes
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DOI：
10.1016/j.jpsychires.2009.11.020
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发表时间：
2010-07-01
影响因子：
4.8
通讯作者：
Kapczinski, Flavio
中科院分区：
文献类型：
--
作者：
Fernandes, Brisa Simoes;Gama, Clarissa Severino;Kapczinski, Flavio
双相情感障碍（BD）已越来越多地与神经可塑性异常相关。以往的研究表明，神经营养素-3（NT-3）在心境障碍的病理生理中发挥作用。这些研究中药物的影响被认为是一种局限性。因此，有必要对无药物与药物治疗的患者进行研究，以评估药物在血清NT-3水平中的作用。约10例躁狂和10例抑郁药物，10例躁狂和10例抑郁药物治疗的BD I型患者与20名对照组的性别和年龄相匹配。采用SCID-I、YMRS和HORS对患者进行评估。与对照组相比，无药物和药物治疗患者的血清NT-3水平增加（无药物/药物治疗组与对照组相比，分别为2.51 +/- 0.59、2.56 +/- 0.44和1.97 +/- 0.33，p < 0.001）。血清NT-3水平在服药和不服药的患者之间没有差异。当根据情绪状态分析患者时，与对照组相比，躁狂和抑郁发作中的血清NT-3水平均升高（躁狂/抑郁患者与对照组相比，分别为2.47 +/- 0.43、2.60 +/- 0.59和1.97 +/- 0.33，p < 0.001）。躁狂症和抑郁症患者血清BDNF水平无差异。结果表明，BD患者血清NT-3水平升高可能与躁狂和抑郁症状的病理生理学有关。(C)2009爱思唯尔有限公司保留所有权利。
Bipolar disorder (BD) has been increasingly associated with abnormalities in neuroplasticity. Previous studies demonstrated that neurotrophin-3 (NT-3) plays a role in the pathophysiology of mood disorders. The influence of medication in these studies has been considered a limitation. Thus, studies with drug-free vs. medicated patients are necessary to evaluate the role of medication in serum NT-3 levels. About 10 manic and 10 depressive drug-free, and 10 manic and 10 depressive medicated patients with BD type I were matched with 20 controls for sex and age. Patients were assessed using SCID-I, YMRS and HORS. Serum NT-3 levels in drug-free and medicated patients is increased when compared with controls (2.51 +/- 0.59, 2.56 +/- 0.44 and 1.97 +/- 0.33, respectively, p < 0.001 for drug-free/medicated vs. control). Serum NT-3 levels do not differ between medicated and drug-free patients. When analyzing patients according to mood states, serum NT-3 levels are increased in both manic and depressive episodes, as compared with controls (2.47 +/- 0.43, 2.60 +/- 0.59 and 1.97 +/- 0.33, respectively, p < 0.001 for manic/depressive patients vs. controls). There is no difference in serum BDNF between manic and depressive patients. Results suggest that increased serum NT-3 levels in BD are likely to be associated with the pathophysiology of manic and depressive symptoms. (C) 2009 Elsevier Ltd. All rights reserved.