Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis.
Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis.
复制标题
胰腺囊性纤维化和支气管扩张中气管支气管分泌物的成分。
作者：
W. S. Chernick;G. Barbero
对囊性纤维化和慢性支气管扩张患者经支气管镜抽吸获得的气管支气管分泌物的主要有机和无机成分进行了分析。囊性纤维化患者的气管支气管分泌物所含的有机物质的重量至少是支气管扩张分泌物的两倍。
氮，碳水化合物，氨基己糖和脂质的分泌物的分析表明，在干重的基础上，在两种类型的分泌物中发现类似数量的这些有机成分。唯一的有机成分，发现是一贯不同的脱氧核糖核酸，较高的含量被发现在囊性纤维化分泌物。
无机成分的分析显示，较高含量的钠和钾的支气管扩张分泌物的湿重和干重的基础上计算时，而磷被认为是较高的囊性纤维化分泌物。
总囊性纤维化分泌物中的钙含量是支气管扩张材料中的两倍;然而，当根据干重计算时，两种类型的分泌物含有相似量的钙。
周围介质的离子组成对高分子量聚合物的影响进行了讨论，并提出了假设，即离子浓度的改变可能是负责囊性纤维化患者的气管支气管分泌物中观察到的特有特征。
Tracheobronchial secretions obtained by bronchoscopic aspiration from patients with cystic fibrosis and patients with chronic bronchiectasis were analyzed for the major organic and inorganic constituents. The tracheobronchial secretions from patients with cystic fibrosis contained, on a weight basis, at least twice the quantity of organic material found in bronchiectatic secretions.
Analysis of the secretions for nitrogen, carbohydrate, hexosamine and lipids indicated that, on a dry weight basis, similar quantities of these organic constituents are found in the two types of secretions. The only organic component which was found to be consistently different was desoxyribonucleic acid; a higher content was found in cystic fibrosis secretion.
Analysis of the inorganic constituents revealed a higher content of sodium and potassium in the bronchiectatic secretion when calculated both on the basis of wet and dry weight, whereas phosphorus was found to be higher in the cystic fibrosis secretion.
The calcium content in the total cystic fibrosis secretion was found to be twice that in the bronchiectatic material; however, when calculated on the basis of dry weight, both types of secretion contained similar amounts of calcium.
The influence of ionic composition of the surrounding media on high molecular weight polymers is discussed and the postulation made that an alteration in the ionic concentration may be responsible for the peculiar characteristics observed in the tracheobronchial secretions of patients with cystic fibrosis.