DOSE FRACTIONATION, DOSE-RATE AND ISO-EFFECT RELATIONSHIPS FOR NORMAL TISSUE RESPONSES
DOSE FRACTIONATION, DOSE-RATE AND ISO-EFFECT RELATIONSHIPS FOR NORMAL TISSUE RESPONSES
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DOI：
10.1016/0360-3016(82)90459-x
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发表时间：
1982-01-01
影响因子：
7
通讯作者：
BARENDSEN, GW
中科院分区：
文献类型：
--
作者：
BARENDSEN, GW
本文分析了动物各种正常组织对分次辐照的反应。分次的影响可以根据一个简单的公式来描述，该公式将诱导细胞效应的有效性与每一分次的剂量相关联：F（D）= a1 D + a2 D2。a1/a2是描述分馏效应的重要参数。各种组织反应的a1/a2值范围广泛，为2-10戈伊[Gray]。本文在回顾放射生物学资料的基础上，提出了一种分析和预测组织耐受性等效应关系的形式，它可作为Ellis的名义标准剂量（NSD）公式及其导出公式的替代。的形式主义的一个基本特征是，三组组织的反应被区分，这可以描述相对于分馏效应的平均值为a1/a2 = 10，5和2.5戈伊，分别。这些基团构成1：a.o.皮肤和肠; 2：结缔组织; 3：a.o.肺和血管系统。剂量率效应可以用类似的形式描述。为了计算临床治疗中应用的等效总剂量，引入了外推耐受剂量（ETD）或外推反应剂量（ERD）的概念。ETD是无限数量的极小组分的耐受剂量。这一概念对于不同分次方案和低剂量率治疗的总和是有用的。一些例子，说明比较的相似性和差异的基础上NSD公式的计算。所描述的形式主义的一个重要特征是，它直接基于放射生物学的见解，并且它提供了比NSD公式中N和T的不同指数的假设更合乎逻辑的概念来解释组织响应的多样性。
An analysis is presented of responses of a variety of normal tissues in animals to fractionated irradiations. The influence of fractionation can be described on the basis of a simple formula relating the effectiveness for induction of cellular effects to the dose per fraction: F(D) = a1D + a2D2. The ratio a1/a2 is derived as an essential parameter for the description of fractionation effects. The values of a1/a2 for responses of various tissues range widely from 2-10 Gy [Gray]. On the basis of the review of radiobiological data, a formalism is developed for the analysis and prediction of iso-effect relations for tissue tolerance, which can be used as an alternative to the nominal standard dose (NSD) formula of Ellis and its derived equations. An essential characteristic of the formalism is that three groups of tissue responses are distinguished which can be described with respect to fractionation effects by average values of a1/a2 = 10; 5 and 2.5 Gy, respectively. These groups comprise a 1:a.o. skin and intestine; 2:connective tissue; 3:a.o. lung and vascular system. Dose rate effects can be described by a similar formalism. For the calculation of equivalent total doses to be applied in clinical treatments, a concept denoted extrapolated tolerance dose (ETD) or extrapolated response dose (ERD) is introduced. ETD is the tolerance dose for an infinite number of very small fractions. This concept is useful for the summation of different fractionated schedules and of low dose rate treatments. A number of examples is presented illustrating similarities and differences in comparison with calculations based on the NSD formula. An important feature of the described formalism is that it is directly based on radiobiological insights and it provides a more logical concept to account for the diversity of tissue responses than the assumption of different exponents of N and T in the NSD formula.