Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography
Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography
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DOI：
10.1117/1.jbo.25.9.095004
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发表时间：
2020-09-01
影响因子：
3.5
通讯作者：
Sampson, David D.
中科院分区：
文献类型：
--
作者：
Gong, Peijun;Heiss, Christian;Sampson, David D.
意义：脉搏是心血管系统的重要特征。外周微血管局部搏动模式的表征目前还不容易获得，这将提供额外的信息来源，这可能对理解动脉硬化、血管老化的病理生理学及其与心血管疾病发展的联系很重要。目的：我们的目的是确认斑点去相关光学相干断层血管成像（OCTA）在各种非接触/接触扫描方案下对无血管组织和周围皮肤微血管的脉动模式的可视化的适用性。结果：五名健康受试者的结果显示，非接触或接触成像的无血管组织和接触成像的单个微血管都有明显的脉搏模式。这些模式分别可能是由脉动压力和脉动血流引起的。脉搏率与脉搏血氧仪的结果吻合良好，证实了脉搏特征反映了脉搏血流动力学。结论：本研究证明了斑点去相关OCTA测量局部周围皮肤脉搏的潜力，并定义了进行此类测量所需的扫描方案。非接触成像应用于无血管组织的搏动性研究和单个微血管中强机械耦合的接触成像。基于该方法和方案的微循环进一步研究是有必要的。(C)作者。
Significance: Pulsatility is a vital characteristic of the cardiovascular system. Characterization of the pulsatility pattern locally in the peripheral microvasculature is currently not readily available and would provide an additional source of information, which may prove important in understanding the pathophysiology of arterial stiffening, vascular ageing, and their linkage with cardiovascular disease development.Aim: We aim to confirm the suitability of speckle decorrelation optical coherence tomography angiography (OCTA) under various noncontact/contact scanning protocols for the visualization of pulsatility patterns in vessel-free tissue and in the microvasculature of peripheral human skin.Results: Results from five healthy subjects show distinct pulsatile patterns both in vessel-free tissue with either noncontact or contact imaging and in individual microvessels with contact imaging. Respectively, these patterns are likely caused by the pulsatile pressure and pulsatile blood flow. The pulse rates show good agreement with those from pulse oximetry, confirming that the pulsatile signatures reflect pulsatile hemodynamics.Conclusions: This study demonstrates the potential of speckle decorrelation OCTA for measuring localized peripheral cutaneous pulsatility and defines scanning protocols necessary to undertake such measurements. Noncontact imaging should be used for the study of pulsatility in vessel-free tissue and contact imaging with strong mechanical coupling in individual microvessels. Further studies of microcirculation based upon this method and protocols are warranted. (C) The Authors.