Physical symptom profiles of depressed and nondepressed patients with cancer
Physical symptom profiles of depressed and nondepressed patients with cancer
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DOI：
10.1191/0269216304pm950oa
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发表时间：
2004-01-01
影响因子：
4.4
通讯作者：
Chang, HK
中科院分区：
文献类型：
--
作者：
Chen, ML;Chang, HK
抑郁和症状严重程度是癌症患者生存的预测因素，但通常彼此相关。本文比较了抑郁和非抑郁癌症患者的躯体症状，并进一步探讨了多种症状对抑郁状态的预测能力。数据收集自121例乳腺癌、食管癌和头颈癌住院患者。使用医院焦虑和抑郁量表将患者分为抑郁（n=30）或非抑郁（n=91）。采用患者疾病症状/体征评估量表评估症状的发生率。总样本中最常见的症状是失眠（发生率= 67%）。抑郁症患者的不适、疼痛、厌食、疲劳和伤口或压疮的发生率明显更高，恶心/呕吐和呼吸困难的发生率无差异。抑郁症患者的症状明显多于非抑郁症患者（平均值= 3.77 vs 2.52）。两组的症状发生率排名相似。同时经历失眠、疼痛、厌食和疲劳的患者患抑郁症的风险更高（比值比= 5.03）。
Depression and symptom severity are predictive of survival in cancer patients, but are often correlated with each other. This paper compares the physical symptom profiles of depressed and nondepressed cancer patients and further examines the predictive ability of multiple symptoms on depressive status. Data were collected from 121 hospitalized patients with breast, oesophageal and head and neck cancer. Patients were categorized as depressed (n=30) or nondepressed (n=91) using the Hospital Anxiety and Depression Scale. Occurrence of symptoms was evaluated with the Patient Disease Symptom/Sign Assessment Scale. The most prevalent symptom in the total sample was insomnia ( occurrence rate = 67%). Insomnia, pain, anorexia, fatigue, and wound or pressure sore occurred significantly more often in depressed patients, with no difference in occurrence rates of nausea/vomiting and dyspnoea. Significantly more symptoms were observed in depressed than in nondepressed patients (mean = 3.77 versus 2.52). Both groups showed similar rankings of symptom occurrence rates. Patients simultaneously experiencing insomnia, pain, anorexia and fatigue had a higher risk of depression (odds ratio = 5.03).