Iodine-containing organic carbonates as investigative radiopaque compounds
Iodine-containing organic carbonates as investigative radiopaque compounds
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含碘有机碳酸酯作为研究不透射线化合物
DOI：
10.1021/jm00234a002
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发表时间：
1976
影响因子：
7.3
通讯作者：
B. N. Newton
中科院分区：
文献类型：
--
作者：
B. N. Newton
制备了碳酸盐键一侧含有碘化芳环，另一侧含有烷基的碳酸盐。芳香族侧基包括对碘苯基、对碘苯基、间碘苯甲基、3，5-二碘苯甲基、间-氨基-2，4，6-三碘苯甲基、间-乙酰氨基-2，4，6-三碘苯甲基、对碘苯乙基、对碘仲苯乙基、3-(对碘苯基)丙基、3-(对碘苯基)丁基、2-(对碘苯基)丁基和2-(碘苯甲基)己基。碳酸盐的烷基部分来自于含有2到10个碳原子的烷基醇。腹腔注射的近似致死剂量从小于1ml/kg到大于15ml/kg不等。目前正在对这些化合物用作脊髓造影术、淋巴造影术、支气管造影术和输卵管造影术的放射物的使用情况进行调查。
: Carbonates containing an iodinated aromatic ring on one side of the carbonate linkage and an alkyl group on the other were prepared. The aromatic side consisted of p-iodophenyl, p-iodobenzyl, m-iodobenzyl, 3,5-diiodobenzyl, m-amino-2,4,6-triiodobenzyl, m-acetamido-2,4,6-triiodobenzyl, p-iodophenethyl, p-iodo-sec-phenethyl, 3-(p-iodophenyl)propyl, 3-(p-iodophenyl)butyl, 2-(p-iodobenzyl)butyl, and 2-(iodobenzyl)hexyl groups. The alkyl portion of the carbonates was derived from alkyl alcohols containing from two to ten carbon atoms. The approximate lethal dose of intraperitoneal injections ranged from less than 1 ml/kg to more than 15 ml/kg. An investigation into the use of these compounds as radiopaques for myelography, lymphography, bronchography, and salpingography is underway.