Androgenesis as a cause of hydatidiform mole.
Androgenesis as a cause of hydatidiform mole.
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雄激素生成是葡萄胎的一个原因。
DOI：
10.1093/jnci/60.1.51
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
M. Sasaki
中科院分区：
文献类型：
--
作者：
N. Wake;N. Takagi;M. Sasaki
q带染色体研究在3个摩尔胎及其亲本中进行，特别关注6对染色体（3号、13- 15号、21号和22号），其中多态性变异经常发生。这六对染色体在鼹鼠细胞中是均匀同态的，而在父系细胞和母系细胞中至少有一对是异态的。进一步的分析提供了强有力的证据，表明鼹鼠从父亲那里继承了两组形态相同的单倍体，而没有从母亲那里继承。因此，雄激素发生似乎与完全葡萄胎的发病机制有因果关系。
Q-band chromosome studies were done in 3 molar conceptuses and their parents, with special attention to six pairs of chromosomes (No. 3, 13--15, 21, and 22) in which polymorphic variants occur frequently. Those six pairs of chromosomes were uniformly homomorphic in moles, whereas at least one of them was heteromorphic in both paternal and maternal cells. Closer analyses provided evidence strongly suggesting that the moles inherited two morphologically identical haploid sets from the father and none from the mother. Thus androgenesis seemed causally related to pathogenesis of complete hydatidiform moles.