Long-term beneficial effects of lung volume reduction surgery on quality of life in patients with chronic obstructive pulmonary disease
Long-term beneficial effects of lung volume reduction surgery on quality of life in patients with chronic obstructive pulmonary disease
复制标题
DOI：
10.1620/tjem.213.157
复制
发表时间：
2007-10-01
影响因子：
2.2
通讯作者：
Kurosawa, Hajime
中科院分区：
文献类型：
--
作者：
Goto, Yoko;Kohzuki, Masahiro;Kurosawa, Hajime
慢性阻塞性肺疾病（COPD）的特征是进行性气流受限，导致劳力性呼吸困难和身体残疾。随后，这些导致难以进行日常生活的日常活动，并影响其健康相关的生活质量（HRQOL）。据报道，肺减容手术（LVRS）是治疗选定的晚期COPD患者的有效治疗方法，可改善肺功能、肺力学、运动耐量和呼吸困难。然而，LVRS对HRQOL的长期影响尚未得到充分研究。因此，在LVRS治疗36个月后的COPD患者中评估了LVRS对一般和疾病特异性HRQOL的影响。19例患者（65.1 ± 7.0 [平均值± S.D.] LVRS组（67.2 ± 5.8岁），单纯LVRS组（67.2 ± 5.8岁）。在这段时间内，两组都给予了最佳药物治疗。在康复前和LVRS后3、12、24和36个月评价一般HRQOL和疾病特异性HRQOL。LVRS后，一般HRQOL显著改善，疾病特异性HRQOL维持长达36个月。在医疗组，疾病特异性HRQOL迅速恶化。总之，与医疗组相比，LVRS对COPD患者HRQOL的长期影响可维持长达36个月。一般和疾病特异性HRQOL的变化不同，这表明两种评估的重要性，特别是在长期随访。- 疾病影响量表;视觉模拟量表;康复;肺减容手术;生活质量。(c)东北大学医学出版社.
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation, which results in exertional dyspnea and physical disability. Subsequently, those cause a difficulty in performing routine activities of daily living and affect their health-related quality of life (HRQOL). Lung volume reduction surgery (LVRS) has been reported to be an effective treatment for selected patients with advanced COPD to improve pulmonary function, lung mechanics, exercise tolerance, and dyspnea. However, the long-term effects of LVRS on HRQOL have not been fully investigated. Therefore the effects of LVRS on generic and disease-specific HRQOL were assessed in patients with COPD following LVRS for 36 months. Nineteen patients (65.1 +/- 7.0 [mean +/- S.D.] years old) who underwent pulmonary rehabilitation plus LVRS (LVRS group), and 8 patients (67.2 +/- 5.8 years old) who did pulmonary rehabilitation but not LVRS (Medical group) were studied. In both groups, optimal medication was given throughout this period. Generic HRQOL and disease-specific HRQOL were evaluated before rehabilitation, and 3, 12, 24, and 36 months after LVRS. Following LVRS, the generic HRQOL was significantly improved and the disease-specific HRQOL was maintained up to 36 months. In Medical group, disease-specific HRQOL rapidly deteriorated. In conclusion, the long-term effects of LVRS on HRQOL in COPD patients were maintained up to 36 months compared with Medical group. Both generic and disease-specific HRQOL changed differently, suggesting the importance of both assessments especially in long-term follow up. - sickness impact profile; visual analogue scale; rehabilitation; lung volume reduction surgery; quality of life. (c) 2007 Tohoku University Medical Press.