Bypassing V1: a direct geniculate input to area MT
Bypassing V1: a direct geniculate input to area MT
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DOI：
10.1038/nn1318
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发表时间：
2004-10-01
影响因子：
25
通讯作者：
Horton, JC
中科院分区：
文献类型：
--
作者：
Sincich, LC;Park, KF;Horton, JC
丘脑核被认为是将感觉信息汇集到大脑的初级皮质区，而初级皮质区又将信号重新传递到高级皮质区。在这里，我们描述了一个直接的投影在猕猴从外侧膝状体核（LGN）的运动选择性中颞区（MT或V5），皮质区以前不被认为是“主要的”。组成神经元主要是koniocellular，发送几乎没有侧支轴突初级视觉皮层（V1）和等于约10%的V1人口支配MT。这条通路可以解释V1损伤后受试者运动敏感性的持续性，更普遍地表明，初级区域损伤后的残余感知可能来自丘脑向“次级”皮层区域的稀疏输入。
Thalamic nuclei are thought to funnel sensory information to the brain's primary cortical areas, which in turn transmit signals afresh to higher cortical areas. Here we describe a direct projection in the macaque monkey from the lateral geniculate nucleus (LGN) to the motion-selective middle temporal area (MT or V5), a cortical area not previously considered 'primary'. The constituent neurons are mostly koniocellular, send virtually no collateral axons to primary visual cortex (V1) and equal about 10% of the V1 population innervating MT. This pathway could explain the persistence of motion sensitivity in subjects following injury to V1, suggesting more generally that residual perception after damage in a primary area may arise from sparse thalamic input to 'secondary' cortical areas.