Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon

Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon
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阿糖胞苷和干扰素治疗进展性多灶性白质脑病的成功结果

DOI:
10.1002/ana.410330415
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发表时间:
1993
影响因子:
11.2
通讯作者:
D. Steiger
D. Steiger
中科院分区:
医学1区
文献类型:
--
作者:
Mrcp M. J. Steiger;G. T. Mrcp;S. G. Mrcp;J. M. FRCPath;MD A. H. V. Schapira;D. Steiger

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进行性多灶性白质脑病的预后很差,很少有患者出现缓解或存活。我们描述了一位37岁的男性,他发展为与结节病相关的进行性多灶性脑白质病。尽管给予阿糖胞苷和阿昔洛韦治疗,他的病情仍在恶化。在加入干扰素后不久,他取得了显著的改善,恢复了完全的功能独立。在这类患者中,除阿糖胞苷外使用干扰素提供了一种值得进一步试验的新治疗方法。
The prognosis of patients with progressive multifocal leukoencephalopathy is poor, with few patients showing remission or surviving. We describe a 37‐year‐old man who developed progressive multifocal leukoencephalopathy in association with sarcoidosis. Despite treatment with cytarabine and acyclovir, he continued to deteriorate. Shortly following the addition of interferon alfa, he made a dramatic improvement, regaining full functional independence. The use of interferon alfa in addition to cytarabine in such patients offers a new therapeutic approach worthy of further trial.
DOI: --
发表时间: 1989-08
期刊: The Journal of pharmacology and experimental therapeutics
影响因子: --
作者:
Dean M. Hartley;D. Choi
通讯作者: Dean M. Hartley;D. Choi