Endocrine Mucin Producing Sweat Gland Carcinoma with Metastasis to Parotid Gland: Not as Indolent as Perceived?
Endocrine Mucin Producing Sweat Gland Carcinoma with Metastasis to Parotid Gland: Not as Indolent as Perceived?
复制标题
产生内分泌粘蛋白的汗腺癌并转移至腮腺：并不像人们想象的那么惰性？
DOI：
10.1007/s12105-021-01353-1
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发表时间：
2021
影响因子：
2.1
通讯作者：
A. Kakkar
中科院分区：
文献类型：
--
作者：
J. Sarangi;Abhilash Konkimalla;Kavneet Kaur;K. Sikka;S. Sen;A. Kakkar
内分泌粘液性汗腺癌是一种罕见的低度恶性皮肤附属器肿瘤，具有神经内分泌分化的证据，主要发生在老年人的眼睑。它与具有神经内分泌特征的乳腺实性乳头状癌非常相似。EMPSGC被认为是皮肤粘液癌的前体，并且术语“粘液癌”也被推荐用于显示与EMPSGC相关的浸润性粘液成分的混合病变。虽然在EMPSGC中有充分的局部复发记录，但直到最近才遇到转移;过去一年中的两份报告描述了从原发性疾病间隔较长时间后从眼睑EMPSGC转移到腮腺。我们报告的情况下，一个78岁的男性眼睑EMPSGC转移到腮腺切除后9年的原发性肿瘤，最初被诊断为低分化癌。长时间间隔后发生转移与上述病例相似，强调需要重新评估该肿瘤的惰性性质。它也旨在提请注意病理学家这种罕见的肿瘤眼睑，往往误诊的主要表现。
Endocrine mucin-producing sweat gland carcinoma (EMPSCG) is a rare, low-grade cutaneous adnexal neoplasm with evidence of neuroendocrine differentiation, predominantly involving the eyelids of elderly. It has a striking resemblance to solid papillary carcinoma of breast which similarly displays neuroendocrine features. EMPSGC is considered a precursor of cutaneous mucinous carcinoma, and the term “mucinous carcinoma” is also recommended for hybrid lesions which reveal an invasive mucinous component associated with EMPSGC. While local recurrences are well- documented in EMPSGC, metastases had not been encountered until very recently; two reports in the past year have described metastases from eyelid EMPSGC to the parotid gland after a prolonged interval from the primary presentation. We report the case of a 78-year-old male with eyelid EMPSGC metastatic to the parotid gland nine years after excision of the primary tumor, which had initially been diagnosed as a poorly differentiated carcinoma. Development of metastasis after a prolonged interval is similar to both the previously described cases, and emphasizes the need to reevaluate the stated indolent nature of this neoplasm. It also aims to draw attention of pathologists to this uncommon tumor of the eyelid which is often misdiagnosed on primary presentation.