CORRELATION OF MOTH SEX-PHEROMONE ACTIVITIES WITH MOLECULAR CHARACTERISTICS INVOLVED IN CONFORMERS OF BOMBYKOL AND ITS DERIVATIVES
CORRELATION OF MOTH SEX-PHEROMONE ACTIVITIES WITH MOLECULAR CHARACTERISTICS INVOLVED IN CONFORMERS OF BOMBYKOL AND ITS DERIVATIVES
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DOI：
10.1073/pnas.72.9.3337
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发表时间：
1975-01-01
影响因子：
11.1
通讯作者：
KIKUCHI, T
中科院分区：
文献类型：
--
作者：
KIKUCHI, T
在双功能单元模型的假设下，研究了家蚕（Bombyx mori）、阿格里亚（Aglia tau）、花斑Endromis versicolora)和大黄蜂（Deilephila euphorbiae） 4种蛾类单一性信息素受体细胞的生物学活性与蚕豆素及其11个衍生物的分子特性之间的显著相关性。用质子受体、质子给体和甲基之间的距离的频率分布模式评估了这12种化合物双功能单元形成的概率，这些距离涉及总共1200种构象。每个物种的生物活性与特定双功能单元形成的概率之间存在高度显著的相关性：Deilephila的质子受体(A)-甲基（Me）单元（A- Me距离：约6 A） （r = 0.94）；Aglia的质子受体(a)-质子供体(D)(a -D：约11a)(r = 0.83)；Bombyx （r = 0.94）和Endromis （r = 0.92）的两个拮抗质子供体-甲基单位（D- Me：分别约为14和5 A，为有利和不利单位）。
Molecular characteristics of bombykol and its 11 derivatives, which reveal significant correlations with biological activities for single sex pheromone receptor cells of four moth species, Bombyx mori, Aglia tau, Endromis versicolora, and Deilephila euphorbiae, were examined on the assumption of the "bifunctional unit model." Probabilities of bifunctional unit formations of those 12 compounds were assessed with frequency distribution patterns of distances between the proton acceptor, the proton donor, and the methyl group involved in a total of 1,200 conformers. A highly significant correlation exists between biological activity for each species and the probability of a particular bifunctional unit formation: a proton acceptor (A)--a methyl group (Me) unit (A--Me distances: about 6 A) for Deilephila (r = 0.94); a proton acceptor (A)--a proton donor (D)(A--D: about 11 A) for Aglia (r = 0.83); two antagonistic proton donor--methyl units (D--Me: about 14 and 5 A for favorable and adverse unit, respectively) for Bombyx (r = 0.94) and Endromis (r = 0.92).