Serum transferrin receptor and transferrin receptor ferritin index identify healthy subjects with subclinical iron deficits
Serum transferrin receptor and transferrin receptor ferritin index identify healthy subjects with subclinical iron deficits
复制标题
DOI：
10.1182/blood.v92.8.2934.420k07_2934_2939
复制
发表时间：
1998-10-15
期刊：
影响因子：
20.3
通讯作者：
Irjala, K
中科院分区：
文献类型：
--
作者：
Suominen, P;Punnonen, K;Irjala, K
尽管血清转铁蛋白受体（sTfR）、血清铁蛋白和sTfR/log铁蛋白比率（TfR-F指数）在缺铁性贫血（ID）诊断中已确立效用，但这些参数的数值（其指示亚临床ID）仍有待明确定义。在这项研究中，65名明显健康的非贫血成年人（22名男性和43名女性）接受了3个月的口服补铁治疗，以评估其对反映铁状态的参数的影响，并确定亚临床缺铁在明显健康的成年人中的患病率。在女性中观察到sTfR，铁蛋白和TfR-F指数值的显着变化，而在男性中，研究的参数均未显示出任何显着变化。男性无缺铁性红细胞生成（IDE），女性有17例（40%）。尽管铁状态受损的个体在常规参考人群中可能有相当数量的代表，但可以使用sTfR、铁蛋白和TfR-F指数测定来容易地识别它们。(C)1998年，美国血液学会。
Despite the established utility of serum transferrin receptor (sTfR), serum ferritin, and the sTfR/log ferritin ratio (TfR-F Index) in the diagnosis of iron deficiency (ID) anemia, the numeric values of these parameters, which are indicative of subclinical ID, remain to be clearly defined. In this study, 65 apparently healthy nonanemic adults (22 men and 43 women) were treated with 3 months of oral iron supplementation to evaluate its effect on parameters reflecting iron status and to determine the prevalence of subclinical iron deficiency in apparently healthy adults. Significant supplementation-induced changes were observed in sTfR, ferritin, and TfR-F Index values in women, whereas in men, none of the studied parameters showed any significant change. Iron-deficient erythropoiesis (IDE) was not observed in men, bur was found in 17 women (40%). Although individuals with a compromised iron status may be represented in substantial numbers in conventional reference populations, they can be readily identified using sTfR, ferri tin, and TfR-F Index determinations. (C) 1998 by The American Society of Hematology.