Reduced olfactory bulb volume in depression-A structural moderator analysis
Reduced olfactory bulb volume in depression-A structural moderator analysis
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DOI：
10.1002/hbm.24024
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发表时间：
2018-06-01
影响因子：
4.8
通讯作者：
Croy, Ilona
中科院分区：
文献类型：
--
作者：
Rottstaedt, Fabian;Han, Pengfei;Croy, Ilona
背景：去除嗅球（OB）会导致啮齿动物出现类似抑郁的行为。在人类中，抑郁症和嗅觉功能之间也存在联系。我们假设人类 OB 体积与抑郁状态相关，并测试了这种潜在的一致性是否受到其他大脑区域结构改变的调节。方法：83 名参与者（32 名重度抑郁症患者和 51 名匹配的健康对照）接受了结构 MR 扫描。比较患者和对照组之间的个体 OB 体积，并通过多元回归分析分析抑郁症和合并症的影响。基于全脑体素的形态测量揭示了与抑郁状态和 OB 体积共同变化的结构。结果：患者的 OB 体积显着减小，与对照组相比，这种减小平均为 17%。 OB 体积与岛叶、上颞叶皮层和杏仁核的体积相关。抑郁症 (beta=-.37)、年龄 (beta=-.25) 和性别 (beta=-.40) 自变量解释了个体 OB 体积变化 (R-2=.37)。 OB 体积和抑郁症之间的相关性通过包括岛叶和颞上回 (STG) 在内的簇的体积减少来调节。结论：OB 体积与人类抑郁症以及对显着性检测至关重要的结构体积有关。我们假设 OB 体积减少会导致神经嗅觉输入减少，从而促进岛叶和 STG 体积减少。因此，OB 体积可能构成易患抑郁症的一个因素。基于嗅觉的深部脑刺激被讨论为未来的治疗方法。
Background: Removal of the olfactory bulb (OB) leads to depression like behavior in rodents. A link between depression and olfactory function is also established in humans. We hypothesized that the human OB volume relates to depressive state and tested whether such a potential coherence is moderated by structural alterations in other brain regions.Methods: Eighty-three participants (32 patients with major depression and 51 matched healthy controls) underwent structural MR scanning. Individual OB volumes were compared between patients and controls and the impact of depression and comorbidity was analyzed with multiple regression analysis. Whole-brain voxel-based morphometry revealed structures co-varying with both depressive state and OB volume.Results: The OB volume of patients was significantly reduced and this reduction averaged out at 17% compared to the controls. The OB volume was correlated to the volume of the insula, superior temporal cortex, and amygdala. The independent variables of depression (beta=-.37), age (beta=-.25), and gender (beta=-.40) explained the individual OB volume variation (R-2=.37). The correlation between OB volume and depression was moderated by volumetric reductions in a cluster including the insula and superior temporal gyrus (STG).Conclusions: The OB volume relates to depression in humans and to the volume of structures which are critical for salience detection. We assume that a reduced OB volume causes diminished neural olfactory input which facilitates volume reduction in the insula and STG. The OB volume may hence constitute a factor of vulnerability to depression. Olfactory-based deep brain stimulation is discussed as a future therapeutic approach.