Acetyl-L-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain
Acetyl-L-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain
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DOI：
10.1016/s0006-8993(98)00319-9
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发表时间：
1998-06-15
期刊：
影响因子：
2.9
通讯作者：
Conti, F
中科院分区：
文献类型：
--
作者：
Aureli, T;Di Cocco, ME;Conti, F
在注射不同C-14和C-13标记葡萄糖后15、30、45、60min处死大鼠，观察乙酰化L肉碱对大鼠脑葡萄糖代谢的影响。乙酰化L肉碱可减少[U-C-14]葡萄糖总(CO_2)-C-14的释放，同时减少[1-C-13]葡萄糖掺入脑氨基酸和三羧酸循环中间产物。而给予乙酰肉碱不影响谷氨酸、谷氨酰胺、氨基丁酸和天冬氨酸不同碳位的C-13标记模式。此外，乙酰-L-肉碱治疗组大鼠脑内新合成的前糖原水平高于未治疗组。这些结果表明，乙酰-L-肉碱能够调节大脑葡萄糖的利用，并为该分子在中枢神经系统中的作用机制提供了新的见解。(C)1998 Elsevier Science B.V.保留所有权利。
The effects of acetyl-L-carnitine on cerebral glucose metabolism were investigated in rats injected with differently C-14- and C-13-labelled glucose and sacrificed after 15, 30, 45, and 60 min. Acetyl-L-carnitine was found to reduce total (CO2)-C-14 release from [U-C-14]glucose along with the decrease in [1-C-13]glucose incorporation into cerebral amino acids and tricarboxylic acid cycle intermediates. However the C-13 labelling pattern within different carbon positions of glutamate, glutamine, GABA, and aspartate was unaffected by acetyl-L-carnitine administration. Furthermore, the cerebral levels of newly-synthesized proglycogen were higher in rats treated with acetyl-L-carnitine than in untreated ones. These results suggest that acetyl-L-carnitine was able to modulate cerebral glucose utilization and provide new insights on the mechanisms of action of this molecule in the central nervous system. (C) 1998 Elsevier Science B.V. All rights reserved.