So-called intracranial germ cell tumours: personal experiences and a theory of their pathogenesis.
So-called intracranial germ cell tumours: personal experiences and a theory of their pathogenesis.
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所谓的颅内生殖细胞肿瘤：个人经历及其发病机制的理论。
DOI：
10.1080/01616412.1989.11739874
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发表时间：
1989
影响因子：
1.9
通讯作者：
T. Seto
中科院分区：
文献类型：
--
作者：
K. Sano;M. Matsutani;T. Seto
我们观察了110例颅内生殖细胞肿瘤(截至1986年底)，其中56%为单型组织学类型，44%为混合型。所有这些病例都接受了手术，然后进行了放射和/或化疗。绒毛膜癌和胚胎癌均在2年内死亡，内胚窦瘤的4年生存率为12.5%。成熟性畸胎瘤的5年生存率(5YSR)和10年生存率(10YSR)分别为78.3%和44.9%。双细胞型肿瘤5YSR为85.8%，10YSR为82.4%。根据肿瘤细胞与间质的关系和胎盘碱性磷酸酶染色的不同，可将其分为两组：(1)生殖细胞瘤和(2)松果体实质起源的松果体瘤(松果体细胞瘤伴淋巴细胞浸润性)。松果体区70%的PTC属于松果体瘤，鞍上区92%的PTC为生殖细胞瘤。生殖细胞瘤的5年生存率为91.4%，10年生存率为91.4%；松果体瘤的5年生存率为78.2%，10年生存率为68.4%。这提示生殖细胞瘤和松果体瘤的生物学特性可能不同。所有这些结果可能会质疑生殖细胞理论的有效性，因为根据该理论，生殖细胞瘤是最良性的，而绒毛膜癌和内胚窦瘤是最恶性的，根据该理论，绒毛膜癌和内胚窦瘤是最恶性的。
We investigated 110 cases of intracranial germ cell tumours (up to the end of 1986), 56% of which showed monotypic histological patterns and 44% were shown to be mixed tumours. All these cases underwent surgery followed by radiation and/or chemotherapy. All cases of choriocarcinoma and embryonal carcinoma died within 2 yr: cases of endodermal sinus tumour also showed poor results (4 yr survival rate was 12.5%). Mature teratoma had a 5 yr survival rate (5YSR) and a 10 yr survival rate (10YSR) of 78.3% each: immature teratoma showed a 5YSR of 44.9%. Two-cell pattern tumours (PTC) showed a 5YSR of 85.8% and a 10YSR of 82.4%. They (PTC) can be divided into two groups (i) germinoma and (ii) pinealoma of pineal parenchyma origin (pineocytoma with lymphocytic infiltration) on the basis of the difference in the tumour cell-stroma relationship and also placental alkaline phosphatase stain. In the pineal region, 70% of PTC belonged to the category of pinealoma and in the suprasellar region, 92% of PTC were germinoma. Germinoma showed a 5YSR of 91.4% and a 10YSR of 91.4%, whereas those of the pinealoma were 78.2% and 68.4% respectively. This suggests that the biological characteristics of germinoma and pinealoma may be different. All these results may bring into question the validity of the germ cell theory, since germinoma, which should be the most undifferentiated according to the theory, was the most benign and choriocarcinoma and endodermal sinus tumour, which should be the most differentiated, were the most malignant in the follow-up study.(ABSTRACT TRUNCATED AT 250 WORDS)