Danish population-based reference data for the EORTC QLQ-C30: associations with gender, age and morbidity
Danish population-based reference data for the EORTC QLQ-C30: associations with gender, age and morbidity
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DOI：
10.1007/s11136-014-0675-y
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发表时间：
2014-10-01
影响因子：
3.5
通讯作者：
Gronvold, Mogens
中科院分区：
文献类型：
--
作者：
Juul, Therese;Petersen, Morten Aagaard;Gronvold, Mogens
一般人群参考数据在解释健康相关生活质量（HRQoL）结果方面很有用，但对于欧洲癌症研究与治疗组织生活质量问卷C30（EORTC QLQ-C30），仅在7个国家发表了此类数据。1992年，丹麦一般人口数据仅收集了EORTC QLQ-C30第1版的妇女数据。由于没有丹麦参考数据存在的男性和女性的QLQ-C30版本3.0，本研究的目的是产生这样的数据，并调查EORTC QLQ-C30的结果和年龄，性别和发病率之间的关联，以及随着时间的推移的趋势。EORTC QLQ-C30通过电子方式和邮件沿着有关社会人口统计学/发病率的简短问卷进行管理，从1，832名个体（3，009名合格个体的60.1%）中获得了答复。不同年龄组的缓解率不同，范围从41.9%（20-29岁）到76.1%（70-79岁）。大多数分量表与年龄和发病率密切相关。在15个量表中的5个量表中，性别之间只有很小的但具有临床意义和统计学显著性差异。当比较丹麦妇女20年前和今天，略有改善功能/减少症状的趋势，观察到，但差异很小，只有三个分量表的统计学显着。这项研究是第一次提出丹麦一般人群的参考值EORTC QLQ-C30版本3.0。年龄和发病率是HRQoL研究中必须考虑的重要潜在混杂因素。
General population reference data are useful in the interpretation of health-related quality of life (HRQoL) results, but for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30), such data have been published for only seven countries. In 1992, Danish general population data were collected from women only for EORTC QLQ-C30 version 1. Since no Danish reference data exists for men and women for the QLQ-C30 version 3.0, the aims of this study were to generate such data and to investigate the associations between EORTC QLQ-C30 outcomes and age, gender and morbidity, as well as trends over time.An age- and gender-stratified random sample of 3,080 Danes was drawn from the Danish Civil Registration System. The EORTC QLQ-C30 was administered electronically and by mail along with a short questionnaire concerning socio-demographics/morbidity.Responses were obtained from 1,832 individuals (60.1 % of 3,009 eligible individuals). Response rates varied across age groups, ranging from 41.9 % (20-29 years) to 76.1 % (70-79 years). The majority of subscales were strongly associated with age and morbidity. Between genders only small, but clinically meaningful and statistically significant differences were found in five out of fifteen scales. When comparing Danish women 20 years ago and today, a tendency toward slightly improved function/reduced symptoms was observed, but the differences were small and statistically significant in only three subscales.This study is the first to present Danish general population reference values for the EORTC QLQ-C30 version 3.0. Age and morbidity are important potential confounders that must be taken into account in HRQoL studies.