Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells
Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells
复制标题
前所未有的糖桥双吲哚选择性抑制神经胶质瘤干细胞
DOI：
10.1016/j.bmc.2018.02.024
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发表时间：
2018-05-01
影响因子：
3.5
通讯作者：
Luo, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Wei, Xin;Dai, Zhi;Luo, Xiao-Dong
与已有报道的单键直接连接的双吲哚不同，alstoniasidines A(1)和B(2)，来自alstoniasidines A(1)和B(2)，具有前所未有的骨架，两个吲哚部分由糖桥接，代表了一种新的双吲哚类型，具有严格胺-葡萄糖吡喃糖-吡啶支架。这两种化合物对人胶质瘤干细胞（GSCs）表现出选择性的细胞毒性，并通过增加白细胞介素1 （IL-1）、肿瘤坏死因子（tnf - α）和裂解型caspase-3的表达诱导caspase-3依赖的外源性凋亡，同时破坏了GSCs的无限增殖和自我更新能力。这一发现可能为选择性杀伤人类胶质瘤干细胞提供新的线索。(C) 2018 Elsevier Ltd.版权所有。
Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-alpha), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells. (C) 2018 Elsevier Ltd. All rights reserved.