The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases.
The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases.
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糖萼及其在血管生理学和血管相关疾病中的作用。
DOI：
10.1007/s13239-020-00485-9
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发表时间：
2021-03
影响因子：
1.8
通讯作者：
Tarbell JM
中科院分区：
文献类型：
--
作者：
Weinbaum S;Cancel LM;Fu BM;Tarbell JM
2007年，这两位资深作者撰写了一篇关于内皮细胞糖帽层的结构和功能的综述(Weinbaum in Annu Rev Bied Eng 9：121-167,2007)。从那时起，由于它在(A)基础血管生理学和(B)血管相关疾病中的重要作用，人们对这种覆盖在血管内皮细胞管腔表面的水凝胶状结构的兴趣激增。本综述将重点介绍自2007年论文发表以来取得的主要进展。使用电子数据库进行了文献检索，主要集中于糖基化在上述两个主要领域中的作用。在这篇综述的(A)部分，描述了已有百年历史的Starling原理的新公式，现在被称为Michel-Weinbaum糖黏土模型或修正的Starling假说，包括新的微妙之处和生理分支。新的见解，机械转导和释放一氧化氮是由于流体剪切力的感觉，由糖萼阐述。本文介绍了近几年来人们在了解糖基化产物的结构和功能方面取得的主要进展，以及基于超分辨随机光学重建显微镜(STORM)测量其厚度和空间化学结构的新技术。正如这篇综述的(B)部分所讨论的，现在已经认识到，与高血压和衰老相关的动脉壁僵硬会导致糖萼降解、内皮功能障碍和血管疾病。除了动脉粥样硬化和心血管疾病外，糖萼在与生活方式有关的疾病(如糖尿病)和癌症中也发挥着重要作用。包括败血症、登革热、寨卡病毒和冠状病毒以及疟疾在内的传染病也涉及糖萼。由于越来越多的人认识到糖萼在一系列疾病中的作用，人们一直在积极寻找方法来保护糖萼不被降解或加强其在疾病环境中的合成。正如我们在这篇综述中所看到的，自2007年的论文以来，我们对GCX的结构、功能和在疾病中的作用的基本理解已经描述了许多重要的发展。继续进行GCX研究的未来是敞开的。
In 2007 the two senior authors wrote a review on the structure and function of the endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9:121–167, 2007). Since then there has been an explosion of interest in this hydrated gel-like structure that coats the luminal surface of endothelial cells that line our vasculature due to its important functions in (A) basic vascular physiology and (B) vascular related diseases. This review will highlight the major advances that have occurred since our 2007 paper. A literature search mainly focusing on the role of the glycocalyx in the two major areas described above was performed using electronic databases. In part (A) of this review, the new formulation of the century old Starling principle, now referred to as the Michel–Weinbaum glycoclayx model or revised Starling hypothesis, is described including new subtleties and physiological ramifications. New insights into mechanotransduction and release of nitric oxide due to fluid shear stress sensed by the glycocalyx are elaborated. Major advances in understanding the organization and function of glycocalyx components, and new techniques for measuring both its thickness and spatio-chemical organization based on super resolution, stochastic optical reconstruction microscopy (STORM) are presented. As discussed in part (B) of this review, it is now recognized that artery wall stiffness associated with hypertension and aging induces glycocalyx degradation, endothelial dysfunction and vascular disease. In addition to atherosclerosis and cardiovascular diseases, the glycocalyx plays an important role in lifestyle related diseases (e.g., diabetes) and cancer. Infectious diseases including sepsis, Dengue, Zika and Corona viruses, and malaria also involve the glycocalyx. Because of increasing recognition of the role of the glycocalyx in a wide range of diseases, there has been a vigorous search for methods to protect the glycocalyx from degradation or to enhance its synthesis in disease environments. As we have seen in this review, many important developments in our basic understanding of GCX structure, function and role in diseases have been described since the 2007 paper. The future is wide open for continued GCX research.
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糖脂和创伤：评论。
DOI：
10.1097/shk.0000000000000513
发表时间：
2016-04
期刊：
Shock (Augusta, Ga.)
影响因子：
--
作者：
Chignalia AZ;Yetimakman F;Christiaans SC;Unal S;Bayrakci B;Wagener BM;Russell RT;Kerby JD;Pittet JF;Dull RO
通讯作者：
Dull RO
醛固酮通过基质金属蛋白酶依赖性糖蛋白糖脂诱导蛋白尿。
影响因子：
19.6
作者：
Butler MJ;Ramnath R;Kadoya H;Desposito D;Riquier-Brison A;Ferguson JK;Onions KL;Ogier AS;ElHegni H;Coward RJ;Welsh GI;Foster RR;Peti-Peterdi J;Satchell SC
通讯作者：
Satchell SC
影响因子：
56.9
作者：
Bates, Mark;Huang, Bo;Zhuang, Xiaowei
通讯作者：
Zhuang, Xiaowei
影响因子：
3.4
作者：
Bartosch, Anne Marie W.;Mathews, Rick;Tarbell, John M.
通讯作者：
Tarbell, John M.
影响因子：
5.3
作者：
Cancel, Limary M.;Ebong, Eno E.;Mensah, Solomon;Hirschberg, Carly;Tarbell, John M.
通讯作者：
Tarbell, John M.