Proton magnetic resonance spectroscopy with metabolite nulling reveals regional differences of macromolecules in normal human brain
Proton magnetic resonance spectroscopy with metabolite nulling reveals regional differences of macromolecules in normal human brain
复制标题
DOI：
10.1002/jmri.10190
复制
发表时间：
2002-11-01
影响因子：
4.4
通讯作者：
Klose, U
中科院分区：
文献类型：
--
作者：
Mader, I;Seeger, U;Klose, U
目的：为了量化的大分子含量在不同的解剖大脑区域，并评估年龄依赖性的大分子concentration.Material和方法：一个短回波时间刺激回波采集模式（STEAM）序列使用无和反转恢复代谢物无效在8-12名健康志愿者。结果：小脑中1.4、2.1和3.0 ppm共振峰最高（P < 0.02），0.9 ppm共振峰显著高于脑桥（P <0.01），小脑中1.4、2.1和3.0 ppm共振峰最高（P <0.02）。在运动皮质，0.9、1.4和2.1ppm的共振频率高于白色物质和脑桥（P < 0.02）。脑桥和白色物质之间没有显著差异。结论：小脑和运动皮质的大分子浓度高于脑桥和白色物质。这可能是由于这些感兴趣体积（VOI）中的灰质比例高于其他区域。
Purpose: To quantify the macromolecular content in different anatomic brain regions and to evaluate an age dependency of the macromolecular concentrations.Material and Methods: A short echo time Stimulated Echo Acquisition Mode (STEAM) sequence was used without and with inversion recovery metabolite nulling in 8-12 healthy volunteers. Quantitation was achieved by an extended LC-Model, and macromolecular resonances at 0.9, 1.4, 2.1, and 3.0 ppm were evaluated.Results: In the cerebellum, the 1.4, 2.1, and 3.0 ppm resonances were highest compared to all other regions (P < 0.02); the 0.9 ppm resonance was significantly higher than that of pons (P < 0.01). In the motor cortex the 0.9, 1.4, and 2.1 ppm resonances were higher than those of white matter and pons (P < 0.02). Pons and white matter did not differ significantly from each other. A significant correlation of the macromolecular concentrations with the age could not be found.Conclusion: There were higher macromolecular concentrations in the cerebellum and motor cortex than in pons or white matter. These were probably due to the higher portions of gray matter in these volumes of interest (VOIs) than in the other regions.