Lack of cell loss following recurrent neonatal seizures
Lack of cell loss following recurrent neonatal seizures
复制标题
DOI：
10.1016/s0165-3806(02)00302-4
复制
发表时间：
2002-04-30
期刊：
影响因子：
--
通讯作者：
Holmes, GL
中科院分区：
文献类型：
--
作者：
Riviello, P;Landrot, ID;Holmes, GL
在新生大鼠中，反复发作与大脑兴奋性和认知的长期变化有关。新生大鼠的反复发作是否会导致大脑皮层细胞丢失尚不清楚。我们对在出生后12天内经历了55次癫痫发作的年轻成年大鼠顶叶皮质、梨状皮质、海马CA3和CA1区的细胞进行了计数。对照组和新生儿癫痫大鼠之间的细胞计数无差异。就像海马体。新生儿的初级皮质和顶叶皮质对麻醉诱导的细胞损失具有抵抗力。(C)2002 Elsevier Science B.V.保留所有权利。
In the neonatal rat recurrent seizures have been associated with long-term changes in cerebral excitability and cognition. Whether recurrent seizures in the neonatal rat lead to cell loss in the cerebral cortex is not known. We counted cells in the parietal cortex, piriform cortex, and CA3 and CA1 hippocampal subfields in young adult rats that had undergone a series of 55 seizures during the first 12 days of life. There were no differences in cell counts between the controls and rats subjected to neonatal seizures. Like the hippocampus. the neonatal pririform and parietal cortex is resistant to seizure-induced cell loss. (C) 2002 Elsevier Science B.V. All rights reserved.