Advances in diagnosis and treatment of short stature, with special reference to the role of growth hormone.
Advances in diagnosis and treatment of short stature, with special reference to the role of growth hormone.
复制标题
身材矮小诊断和治疗的进展，特别提到生长激素的作用。
DOI：
10.1016/s0022-3476(84)80472-2
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Rosenfield,RL
中科院分区：
文献类型：
--
作者：
Schaff-Blass,E;Burstein,S;Rosenfield,RL
极度矮小的身材不仅会造成身体上的限制，还会影响心理社会的适应。直到最近，矫正矮小身材的机会是有限的，因为，实际上！目的：人类生长激素仅适用于有生长激素缺乏症的患者。这一限制是由于从人类尸体脑垂体中提取的生长激素供应有限，因为只有人类来源的生长激素对人类有效。随着生长激素纯化技术和基因工程的进步，生长激素的供应开始增加。因此，医生可以预期越来越多的家庭为身材矮小的儿童寻求激素治疗。虽然如果儿童没有明确的病症，这种治疗的可取性是有争议的，但照顾儿童和青少年的医生将被要求帮助了解情况
EXTREME SHORT STATURE not only imposes physical limitations, it can affect psychosocial adjustment as well. Until recently, opportunities for correction of short stature were limited because, for practica! purposes, human growth hormone was available only for patients with documented growth hormone deficiency. This constraint was dictated by the limited supply of hGH extracted from human cadaver pituitary glands because only GH of human origin is effective in humans. With advances in hGH purification techniques and genetic engineering, the supply of hGH is beginning to increase. Therefore, physicians can expect an increasing number of families to seek hormone treatment for children with short stature. Although the advisability of such treatment is controversial if the child does not have a clearly defined condition, physicians caring for children and adolescents will be asked to help make informed