Responding for brain stimulation reward in the bed nucleus of the stria terminalis in alcohol-preferring rats following alcohol and amphetamine pretreatments
Responding for brain stimulation reward in the bed nucleus of the stria terminalis in alcohol-preferring rats following alcohol and amphetamine pretreatments
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DOI：
10.1002/syn.20437
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发表时间：
2007-11-01
期刊：
影响因子：
2.3
通讯作者：
June, Harry L.
中科院分区：
文献类型：
--
作者：
Eiler, Willlm J. A., II;Hardy, Lathen, III;June, Harry L.
据报道，远交种大鼠在系统滥用药物后，终纹床核（BNST）释放的细胞外多巴胺（DA）水平增加。本研究考察了嗜酒大鼠脑刺激奖励（BSR）在脑中脑st作为支持操作反应的新位点，同时确定了乙醇（EtOH） （0.125-1.25 g/kg, i.p）和安非他明（0.25-1.60 mg/kg, i.p）对脑刺激奖励（BSR）的增强作用。还检查了D1受体阻断对任何观察到的增强的减弱能力。手术植入后，酒精偏好(P)和非偏好（NP）大鼠对一系列下降频率（300-20 Hz）有反应，通过频率-频率范式进行评估。结果表明，脑脊液能支持P大鼠的BSR，而不支持NP大鼠的BSR。此外，安非他明预处理使P大鼠的频率函数显著左移，在其他三个奖励阈值测量中观察到显著降低，而EtOH只降低了产生反应所需的最低频率。对侧伏隔核单侧输注D1受体拮抗剂SCH 23390 (5.0 μ g)，成功地减弱了全身安非他明的作用。结果表明，BNST能够支持P大鼠的BSR表现，但不支持NP大鼠，这可能是由于P大鼠先天DA“缺乏”的边缘系统对电刺激诱导的BSR释放的敏感性增加。
The bed nucleus of the stria terminalis (BNST) has been reported to release increased levels of extracellular dopamine (DA) following the systemic administration of abused drugs in outbred rats. This study examined the BNST as a novel locus for supporting operant responding for brain stimulation reward (BSR) in rats bred for alcohol preference while determining any potentiating effects of ethanol (EtOH) (0.125-1.25 g/kg, i.p.) and amphetamine (0.25-1.60 mg/kg, i.p.) on BSR within the BNST. Also examined was the capability of D1 receptor blockade to attenuate any observed potentiation. Following surgical implantation, alcohol-preferring (P) and non-preferring (NP) rats responded to a range of descending frequencies (300-20 Hz) as evaluated by a rate-frequency paradigm. The results revealed that the BNST was capable of supporting BSR in P but not NP rats. Also, amphetamine pretreatment produced a significant leftward shift in the rate-frequency function in P rats with significant reductions observed in three other measures of reward threshold, while EtOH only lowered the minimum frequency needed to produce responding. The effects of systemic amphetamine were successfully attenuated by the unilateral infusion of the D1 receptor antagonist SCH 23390 (5.0 mu g) into the contralateral nucleus accumbens. The results suggest the BNST is capable of supporting BSR performance in P, but not NP rats, possibly due to increased sensitivity to the electrical stimulation-induced DA release of BSR in the innately DA "deficient" limbic system of P rats.