Association Between Maternal Smoking During Pregnancy and Birth Weight: An Appropriately Adjusted Model From the Japan Environment and Children's Study.
Association Between Maternal Smoking During Pregnancy and Birth Weight: An Appropriately Adjusted Model From the Japan Environment and Children's Study.
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DOI：
10.2188/jea.je20150185
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发表时间：
2016-07-05
影响因子：
4.7
通讯作者：
Yamagata Z
中科院分区：
文献类型：
--
作者：
Suzuki K;Shinohara R;Sato M;Otawa S;Yamagata Z
目前还没有大规模的全国性的基于人群的研究，以检查母亲在怀孕期间吸烟状况对出生体重的影响，同时控制临床信息，社会经济地位和母亲体重。因此，本研究旨在确定母亲在怀孕期间吸烟状况与出生体重之间的关联，同时考虑这些混杂因素。这项研究检查了2011年开始的一项大型全国性出生队列研究的第一年固定数据集。该数据集包括2011年12月31日之前出生的9369名单胎婴儿的信息。将儿童分为4组进行统计分析：不吸烟（NS），怀孕前戒烟，怀孕早期戒烟和吸烟（SM）的母亲所生的儿童。对每种性别进行多元线性回归模型，以检查母亲怀孕早期吸烟状况与胎儿生长之间的关系。在控制协变量后，使用最小二乘法估计出生体重。在控制了潜在的混杂因素后，母亲在怀孕期间的吸烟状况与出生体重显著相关。NS组和SM组男女婴儿出生体重差异均有显著性（男婴3096.2g比SM组2959.8g，P < 0.001;女婴3018.2g比SM组2893.7g，P < 0.001）。利用日本一项大型全国性出生队列研究的数据，我们发现母亲在怀孕期间吸烟可能会使出生体重减少125-136 g。
There has been no large nationwide population-based study to examine the effects of maternal smoking status during pregnancy on birth weight that simultaneously controlled for clinical information, socioeconomic status, and maternal weight. Thus, this study aimed to determine the association between maternal smoking status during pregnancy and birth weight, while taking these confounding factors into consideration. This study examined the first-year fixed dataset from a large nationwide birth cohort study that commenced in 2011. The dataset consisted of information on 9369 singleton infants born before December 31, 2011. Children were divided into 4 groups for statistical analysis: those born to mothers who did not smoke (NS), who quit smoking before pregnancy, who quit smoking during early pregnancy, and who smoked (SM). Multiple linear regression models were conducted for each sex to examine the association between maternal smoking status during early pregnancy and fetal growth. Birth weight was estimated using the least-squares method after controlling for covariates. After controlling for potential confounding factors, maternal smoking status during pregnancy was significantly associated with birth weight. There was a significant difference in birth weight between NS and SM for both male and female infants (male infants, 3096.2 g [NS] vs 2959.8 g [SM], P < 0.001; female infants, 3018.2 g [NS] vs 2893.7 g [SM], P < 0.001). Using data from a large nationwide birth cohort study in Japan, we have shown that maternal smoking during pregnancy may reduce birth weight by 125–136 g.