Integral radiation dose to normal structures with conformal external beam radiation
Integral radiation dose to normal structures with conformal external beam radiation
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DOI：
10.1016/j.ijrobp.2005.11.005
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发表时间：
2006-03-01
影响因子：
7
通讯作者：
Mehta, MP
中科院分区：
文献类型：
--
作者：
Aoyama, H;Westerly, DC;Mehta, MP
背景：本研究旨在评估正常组织从前列腺癌调强放射治疗（IMRT）中获得的积分（ID）。方法和材料：25个放射治疗计划，包括使用6 MV（6MV-IMRT）和20 MV（20MV-IMRT）的传统直线加速器的IMRT，以及使用6 MV（6MV-3DCRT）和20的三维适形放射治疗（3DCRT）。针对 5 名局限性前列腺癌患者创建了 MV (20MV-3DCRT) 和使用断层放疗 (6MV) 的 IMRT (Tomo-IMRT)。根据剂量体积直方图计算正常组织 (NTID) 接受的 ID（平均剂量 X 组织体积）。结果：6MV-IMRT 的 NTID 比 6MV-3DCRT 低 5.0%；20 MV 射束计划的 NTID 降低。与 6MV-3DCRT 相比，Tomo-IMRT 的 NTID 降低了 7.7%-11.2%，与 6MV-3DCRT 相比，6MV-IMRT 使直肠壁和阴茎球的 ID 分别进一步降低了 11.9% 和 16.5%。结论：3DCRT 和 IMRT 之间的 NTID 差异较小，与 6 MV 计划相比，断层放疗相对于传统 IMRT 和 3DCRT 的优势已在以下方面得到证实（与 6MV-3DCRT 相比，保留直肠壁和阴茎球，同时略微降低 NTID。C）2006 Elsevier Inc.。
Background: This study was designed to evaluate the integral (lose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer.Methods and Materials: Twenty-five radiation treatment plans including IMRT using a conventional linac with both 6 MV (6MV-IMRT) and 20 MV (20MV-IMRT), as well as three-dimensional conformal radiotherapy (3DCRT) using 6 MV (6MV-3DCRT) and 20 MV (20MV-3DCRT) and IMRT using tomotherapy (6MV) (Tomo-IMRT), were created for 5 patients with localized prostate cancer. The ID (mean dose X tissue volume) received by normal tissue (NTID) was calculated from dose-volume histograms.Results: The 6MV-IMRT resulted in 5.0% lower NTID than 6MV-3DCRT; 20 MV beam plans resulted in 7.7%-11.2% lower NTID than 6MV-3DCRT. Tomo-IMRT NTID was comparable to 6MV-IMRT. Compared with 6MV-3DCRT, 6MV-IMRT reduced IDs to the rectal wall and penile bulb by 6.1% and 2.7%, respectively. Tomo-IMRT further reduced these IDs by 11.9% and 16.5%, respectively. The 20 MV did not reduce IDs to those structures.Conclusions: The difference in NTID between 3DCRT and IMRT is small. The 20 MV plans somewhat reduced NTID compared with 6 MV plans. The advantage of tomotherapy over conventional IMRT and 3DCRT for localized prostate cancer was demonstrated in regard to (lose sparing of rectal wall and penile bulb while slightly decreasing NTID as compared with 6MV-3DCRT. C) 2006 Elsevier Inc.