Population Differences in Transcript-Regulator Expression Quantitative Trait Loci
Population Differences in Transcript-Regulator Expression Quantitative Trait Loci
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DOI：
10.1371/journal.pone.0034286
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发表时间：
2012-03-27
期刊：
影响因子：
3.7
通讯作者：
Lin, Xihong
中科院分区：
文献类型：
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作者：
Bushel, Pierre R.;McGovern, Ray;Lin, Xihong
基因表达数量性状基因座(EQTL)可用于识别与疾病相关的单核苷酸多态(SNPs)。有时，基因变异可能与疾病表现中涉及的主调控因子有关。主调控子下游的靶基因通常是共表达的，并具有共同的生物学功能。因此，通过识别与转录调控基因(TR)靶标相关的SNP来筛选eQTL是可行的。我们利用TRs和SNPs的已知靶标的基因表达进行多元回归，以确定欧洲(CEU)和非洲(YRI)HapMap群体中的TReQTL。名义p值为
Gene expression quantitative trait loci (eQTL) are useful for identifying single nucleotide polymorphisms (SNPs) associated with diseases. At times, a genetic variant may be associated with a master regulator involved in the manifestation of a disease. The downstream target genes of the master regulator are typically co-expressed and share biological function. Therefore, it is practical to screen for eQTLs by identifying SNPs associated with the targets of a transcript-regulator (TR). We used a multivariate regression with the gene expression of known targets of TRs and SNPs to identify TReQTLs in European (CEU) and African (YRI) HapMap populations. A nominal p-value of