A QUANTITATIVE METHOD FOR MEASURING SPONTANEOUS GASTRIC SECRETION IN THE RAT
A QUANTITATIVE METHOD FOR MEASURING SPONTANEOUS GASTRIC SECRETION IN THE RAT
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DOI：
10.1016/s0016-5085(54)80008-4
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发表时间：
1954-01-01
期刊：
影响因子：
29.4
通讯作者：
GRUENSTEIN, M
中科院分区：
文献类型：
--
作者：
SHAY, H;SUN, DCH;GRUENSTEIN, M
大鼠胃粘膜及胃分泌物。图1示出了雄性大鼠的总酸排出量（mEq/4小时）对重量（克）的一般回归线;用最小二乘法将这条线拟合到来自137个个体观察的数据30。这个问题被分成五组研究，每组在101至200克的范围内以20克的增量连续增加体重（饥饿后的体重）。由于一般回归线的回归系数和相关系数高度显著，零假设的概率小于0.01（表1），因此可以得出结论：大鼠的总酸排出量随着体重的增加而增加。每个体重组的总酸排出量的平均值几乎正好落在一般回归线上，一般回归的平均值差异显著性的F检验表明，回归的小偏差不显著（表1）。散点图（图1）显示总酸输出量回归的个体差异非常大。单个观察值的估计标准误差（以整个137只大鼠组的平均值的百分比表示）为42.9%。这表明，如果从这些数据中得出任何结论，
RESULTSWeight of the Rat and the Gastric Secretion. Fig. 1 shows the general regression line of the total acid output in mEqj4 hours on weight in grams of the male rat; this line was fitted to the data from 137 individual observations by the method of the least squares30• The problem had been studied in five groups, each group successively increasing in weight by 20 gram increments in the range from 101 to 200 grams (post-starvation weight). Since the regression coefficient and the correlation coefficient of the general regression line are highly significant with a probability for null hypothesis less than 0.01 (Table 1), the conclusion is warranted that total acid output in the rat increases with an increase in body weight. The mean values for total acid output of each weight group fell almost exactly on the general regression line, and F test for significance of the difference of the means from general regression showed that the small deviations from regression were not significant (Table 1). The scattergram (Fig. 1) shows very wide individual variations from regression in total acid output. The standard error of estimate of a single observation expressed as per cent of the mean for the entire group of 137 rats was found to be 42.9%. This indicates how hazardous it would be to draw any conclusions from