Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.
Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.
复制标题
对革兰氏阳性病原体具有杀菌活性的天然产物衍生物，包括耐甲氧西林金黄色葡萄球菌和耐万古霉素粪肠球菌。
DOI：
10.1016/j.bmcl.2010.06.146
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发表时间：
2010
影响因子：
2.7
通讯作者：
Priestley,NigelD
中科院分区：
文献类型：
--
作者：
Phillips,JoshuaB;Smith,AdrienneE;Kusche,BrianR;BessetteJr,BradleyA;Swain3rd,PWhitney;Bergmeier,StephenC;McMills,MarkC;Wright,DennisL;Priestley,NigelD
We have shown that the intentional engineering of a natural product biosynthesis pathway is a useful way to generate stereochemically complex scaffolds for use in the generation of combinatorial libraries that capture the structural features of both natural products and synthetic compounds. Analysis of a prototype library based upon nonactic acid lead to the discovery of triazole-containing nonactic acid analogs, a new structural class of antibiotic that exhibits bactericidal activity against drug resistant, Gram-positive pathogens including Staphylococcus aureus and Enterococcus faecalis.
