Prevalence of migraine in persons with the 3243A>G mutation in mitochondrial DNA
Prevalence of migraine in persons with the 3243A>G mutation in mitochondrial DNA
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DOI：
10.1111/ene.12832
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发表时间：
2016-01-01
影响因子：
5.1
通讯作者：
Ashina, M.
中科院分区：
文献类型：
--
作者：
Guo, S.;Esserlind, A. -L.;Ashina, M.
背景和目的：在过去的三十年中，线粒体功能障碍被认为是偏头痛发病机制中的一个潜在机制。方法：在这项横断面研究中，纳入了2012年5月至2014年10月期间57例mDNA 3243 A> G突变携带者。作为对照组，使用了我们对丹麦人偏头痛的流行病学研究中基于人群的队列。头痛和偏头痛的历史是通过电话采访，根据一个有效的半结构式问卷调查，由训练有素的医生进行。结果：偏头痛的患病率是显着高于携带3243 A>G突变的人比对照组（58%比18%; P < 0.001）。这适用于两个亚型的偏头痛，偏头痛没有先兆（47%对12%; P < 0.001）和有先兆的偏头痛（18% vs. 6%; P < 0.001），女性（58% vs. 24%; P < 0.001）和男性（58%对12%; P < 0.001）。结论：发现mDNA 3243 A>G突变的人偏头痛患病率高，这一发现表明线粒体功能障碍的单基因遗传性疾病与偏头痛易感性之间存在临床关联。线粒体DNA畸变可能参与偏头痛的发病机制。
Background and purpose: Over the last three decades mitochondrial dysfunction has been postulated to be a potential mechanism in migraine pathogenesis. The lifetime prevalence of migraine in persons carrying the 3243A>G mutation in mitochondrial DNA was investigated.Methods: In this cross-sectional study, 57 mDNA 3243A>G mutation carriers between May 2012 and October 2014 were included. As a control group, a population-based cohort from our epidemiological studies on migraine in Danes was used. History of headache and migraine was obtained by telephone interview, based on a validated semi-structured questionnaire, performed by trained physicians.Results: The prevalence of migraine is significantly higher in persons carrying the 3243A>G mutation than in controls (58% vs. 18%; P < 0.001). This applies for both subforms of migraine, migraine without aura (47% vs. 12%; P < 0.001) and migraine with aura (18% vs. 6%; P < 0.001), and in females (58% vs. 24%; P < 0.001) and males (58% vs. 12%; P < 0.001) for any migraine.Conclusions: A high prevalence of migraine in persons with the mDNA 3243A>G mutation was found. This finding suggests a clinical association between a monogenetically inherited disorder of mitochondrial dysfunction and susceptibility to migraine. Mitochondrial DNA aberrations may contribute to the pathogenesis of migraine.