Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma
Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma
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DOI：
10.1007/s10147-014-0710-6
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发表时间：
2015-04-01
影响因子：
3.3
通讯作者：
Sugihara, Kazumasa
中科院分区：
文献类型：
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作者：
Kamikawa, Yoshiaki;Kanmura, Yuji;Sugihara, Kazumasa
MUC1和MUC4都是大分子糖蛋白，在包括口腔鳞状细胞癌(OSCC)在内的许多人类上皮性肿瘤中是预后较差的独立指标。然而，MUC1和MUC4在口腔鳞癌中共同表达的临床意义尚未见报道。本研究的目的是探讨MUC1和MUC4在口腔鳞癌中的共表达情况，并分析其在口腔鳞癌中的预后意义。MUC1和MUC4的过度表达呈正相关(p<；0.0001)，MUC1和MUC4的联合表达是反映肿瘤大小(p=0.014)、淋巴结转移(0.0001)、肿瘤分期(p=0.006)、弥漫侵袭(p=0.028)和血管侵犯(p=0.014)等肿瘤侵袭性的有力指标。MUC1/MUC4双阳性患者的总体和无病生存率最差。多因素分析显示，MUC1MUC4双阳性是影响口腔鳞癌患者总生存率和无瘤生存期的独立预后因素(p=0.007和p=0.0019)，以及局部复发(p=0.0025)，提示联合检测MUC1MUC4可以预测口腔鳞癌患者的预后。这一组合也是预测区域复发的有用标志。MUC1和MUC4可能是口腔鳞癌治疗方法选择的有吸引力的靶点。
Both MUC1 and MUC4 are high molecular weight glycoproteins and are independent indicators of worse prognosis in many human epithelial cancers including oral squamous cell carcinoma (OSCC). However, there has been no investigation of the clinical importance of the co-expression of MUC1 and MUC4 in OSCC. The aim of this study was to evaluate the co-expression profile of MUC1/MUC4 and analyze the prognostic significance in OSCC.We examined the expression profile of MUC1 and MUC4 in OSCC tissues from 206 patients using immunohistochemistry. The co-expression profile of MUC1/MUC4 and its prognostic significance in OSCC was statistically analyzed.MUC1 and MUC4 overexpression were strongly correlated with each other (p < 0.0001) and a combination of both MUC1 and MUC4 expression was a powerful indicator for tumor aggressiveness such as tumor size (p = 0.014), lymph node metastasis (0.0001), tumor stage (p = 0.006), diffuse invasion (p = 0.028), and vascular invasion (p = 0.014). The MUC1/MUC4 double-positive patients showed the poorest overall and disease-free survival. Multivariate analysis revealed that MUC1/MUC4 double-positivity was the strong independent prognostic factor for overall and disease-free survival (p = 0.007 and (p = 0.0019), in addition to regional recurrence (p = 0.0025).Taken together, these observations indicate that the use of a combination of MUC1/MUC4 can predict outcomes for patients with OSCC. This combination is also a useful marker for predicting regional recurrence. MUC1 and MUC4 may be attractive targets for the selection of treatment methods in OSCC.