Patient preferences in retinal drug delivery.
Patient preferences in retinal drug delivery.
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DOI：
10.1038/s41598-021-98568-7
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发表时间：
2021-09-23
影响因子：
4.6
通讯作者：
Corson TW
中科院分区：
文献类型：
--
作者：
Jacobs B;Palmer N;Shetty T;Dimaras H;Hajrasouliha A;Jusufbegovic D;Corson TW
视网膜血管疾病（RVD）通常采用玻璃体内（IVT）注射药物治疗，患者依从性相对较低，存在潜在风险。正在进行的研究探索替代RVD治疗，包括滴眼液和口服片剂。本研究调查了接受IVT注射治疗的RVD患者，以确定影响低依从率的因素，同时评估治疗方法偏好。通过向格利克眼科研究所通过IVT注射治疗的患者发送经IRB批准的自我调查，收集人口统计学数据、观点和治疗偏好。从受访者的医疗记录中确定人口统计学、诊断和治疗。将性别、年龄和接受的IVT注射次数用作分层。五级Likert式量表和t检验评价反应和分层比较。应答人群中最常见的诊断（n = 54;应答率= 5%）为年龄相关性黄斑变性、黄斑水肿和糖尿病视网膜病变。受访者的教育水平、收入和年龄各不相同。大多数人（83%）承认在首次IVT注射前感到焦虑，但80%的人报告愿意无限期接受IVT注射，首选眼科医生每1-3个月就诊一次。76%的受访者更喜欢滴眼液而不是IVT注射，而65%的受访者更喜欢口服片剂，这是由于IVT注射的几个负面因素和滴眼液的积极因素。分层组在回答调查问题方面没有差异。RVD患者将接受IVT注射以保护视力，但首选其他给药方法，如滴眼液或口服片剂。因此，这些发现进一步强调了RVD治疗的滴眼液和口服治疗剂的开发。
Retinal vascular diseases (RVDs) are often treated with intravitreally (IVT) injected drugs, with relatively low patient compliance and potential risks. Ongoing research explores alternative RVD treatments, including eye drops and oral tablets. This study surveyed RVD patients treated with IVT injections to establish factors influencing low compliance rates while gauging treatment delivery method preferences. Demographics, perspectives, and treatment preferences were collected via IRB-approved, self-administered survey sent to Glick Eye Institute patients treated via IVT injections. Demographics, diagnoses, and treatments were ascertained from respondents’ medical records. Gender, age, and number of IVT injections received were used as stratifications. Five-level Likert-style scales and t-tests evaluated responses and stratification comparisons. The most common diagnoses in the respondent population (n = 54; response rate = 5%) were age-related macular degeneration, macular edema, and diabetic retinopathy. Respondents had varying levels of education, income, and age. Most (83%) admitted feeling anxious prior to their first IVT injection, but 80% reported willingness to receive IVT injections indefinitely, with a preference for ophthalmologist visits every 1–3 months. Eye drops would be preferred over IVT injections by 76% of respondents, while 65% preferred oral tablets, due to several perceived negative factors of IVT injections and positive factors for eye drops. Stratified groups did not differ in responses to survey questions. RVD patients will accept IVT injections for vision preservation, but alternative delivery methods like eye drops or oral tablets would be preferred. Thus, development of eye drop and oral therapeutics for RVD treatment is further emphasized by these findings.
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影响因子：
3.7
作者：
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通讯作者：
Burton M
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4.6
作者：
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Corson TW
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通讯作者：
Robin AL