Induction and analysis of nephrotoxic serum nephritis in mice.

Induction and analysis of nephrotoxic serum nephritis in mice.
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DOI:
10.1007/978-1-4939-0882-0_15
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发表时间:
2014-01-01
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Vielhauer, Volker
Vielhauer, Volker
中科院分区:
其他
文献类型:
--
作者:
Hoppe, John M;Vielhauer, Volker

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肾毒性血清肾炎(NTN)模型是实验性肾小球肾炎(GN)研究的重要组成部分。在这里,我们讨论了如何小鼠NTN模型可以诱导和有效地用于模拟免疫复合物介导的GN。此外,我们通过比较病理生理学和表型表现来区分异源和自体模型。
The nephrotoxic serum nephritis (NTN) model is an integral part of experimental glomerulonephritis (GN) research. Here, we discuss how the murine NTN model can be induced and effectively used to mimic an immune complex-mediated GN. Further, we differentiate between heterologous and autologous models by comparing pathophysiology and phenotypic manifestations.