A 20/20 view of ANT function in mitochondrial biology and necrotic cell death
A 20/20 view of ANT function in mitochondrial biology and necrotic cell death
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DOI：
10.1016/j.yjmcc.2020.05.012
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发表时间：
2020-07-01
影响因子：
5
通讯作者：
Molkentin，Jeffery D.
中科院分区：
文献类型：
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作者：
Bround，Michael J.;Bers，Donald M.;Molkentin，Jeffery D.
腺苷核苷酸转位酶 (ANT) 家族蛋白是参与能量稳态和细胞死亡的线粒体内膜蛋白。 ANT 蛋白的主要功能是将胞质 ADP 与基质 ATP 交换，促进新合成的 ATP 输出到细胞，同时为线粒体提供新的 ADP 底物。因此，ANT 蛋白对于维持所有真核细胞的能量稳态至关重要。证据还表明，ANT 构成线粒体通透性转换孔 (MPTP) 的成孔成分，MPTP 是一种在线粒体内膜中形成的结构，被认为是受调控的坏死细胞死亡的基础。此外，新兴研究表明 ANT 蛋白对于线粒体解偶联和促进线粒体自噬也至关重要。因此，ANT 是多功能蛋白质，有望参与线粒体生物学的多个方面以及细胞死亡的更大调节，这将在本文中讨论。
The adenosine nucleotide translocase (ANT) family of proteins are inner mitochondrial membrane proteins involved in energy homeostasis and cell death. The primary function of ANT proteins is to exchange cytosolic ADP with matrix ATP, facilitating the export of newly synthesized ATP to the cell while providing new ADP substrate to the mitochondria. As such, the ANT proteins are central to maintaining energy homeostasis in all eukaryotic cells. Evidence also suggests that the ANTs constitute a pore-forming component of the mitochondrial permeability transition pore (MPTP), a structure that forms in the inner mitochondrial membrane that is thought to underlie regulated necrotic cell death. Additionally, emerging studies suggest that ANT proteins are also critical for mitochondrial uncoupling and for promoting mitophagy. Thus, the ANTs are multifunctional proteins that are poised to participate in several aspects of mitochondrial biology and the greater regulation of cell death, which will be discussed here.