Role for acetylcholine in mediating effects of light on reproduction.
Role for acetylcholine in mediating effects of light on reproduction.
复制标题
乙酰胆碱在介导光对生殖的影响中的作用。
DOI：
10.1126/science.6849121
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Turek,FW
中科院分区：
文献类型：
--
作者：
Earnest,DJ;Turek,FW
一天的长度，或者说光周期，调节着金黄地鼠每年的繁殖活动周期。夜间脑室注射胆碱能激动剂卡巴胆碱可阻止短日光周期对睾丸功能的抑制作用，而白天则不然。夜间的短光脉冲也能阻止短日照导致的睾丸退化。这些发现表明，乙酰胆碱可能在将有关明暗环境的信息传递到下丘脑-垂体-性腺轴的机制中发挥重要作用。
The length of day, or photoperiod, regulates the annual cycle of reproductive activity in the golden hamster. The inhibitory effects of a short-day photoperiod on testicular function were prevented by nighttime, but not daytime, intraventricular injections of carbachol, a cholinergic agonist. Short pulses of light during the night also block short-day induced testicular regression. The findings suggest that acetylcholine may play an important role in the mechanism through which information about the light-dark environment is transferred to the hypothalamic-pituitary-gonadal axis.