Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury.
Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury.
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DOI：
10.1155/2018/1275713
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发表时间：
2018
影响因子：
--
通讯作者：
Yamazaki M
中科院分区：
文献类型：
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作者：
Ikumi A;Hara Y;Okano E;Kohyama S;Arai N;Taniguchi Y;Sugaya H;Yoshioka T;Kanamori A;Yamazaki M
手指神经对正常的手部功能非常重要。除了常规疗法如神经松解、直接修复和自体/同种异体移植之外，还存在施用生长因子和细胞以促进神经再生的新疗法。富血小板血浆（PRP）是一种经证实对肌肉骨骼疾病具有治疗效果的自体产品，是周围神经损伤的新治疗选择。我们假设PRP可以刺激指神经损伤的愈合。在本病例报告中，在神经松解术期间对一名患有指神经挤压伤的28岁健康女性进行了PRP术中局部给药。伤后五周，由于严重的无法控制的神经性疼痛和食指感觉神经动作电位的衍生而进行手术。通过体格检查、疼痛视觉模拟评分和神经传导检查评估疗效。术后，神经性疼痛得到早期缓解，功能恢复良好，无PRP相关不良事件。本病例报告证明了术中PRP在急性期促进神经挤压伤愈合过程和减少神经性疼痛，从而促进周围神经挤压伤愈合的治疗潜力。
The digital nerves are important for normal hand function. In addition to conventional therapies such as neurolysis, direct repair, and auto/allografts, new treatments administering growth factors and cells for promoting nerve regeneration exist. Platelet-rich plasma (PRP), an autologous product with proven therapeutic effects for musculoskeletal disorders, is a new treatment option for peripheral nerve injury. We hypothesized that PRP could stimulate healing of digital nerve injuries. In the current case report, intraoperative local administration of PRP was performed during neurolysis surgery for a healthy 28-year-old woman with digital nerve crush injury. Five weeks postinjury, surgery was performed due to severe uncontrollable neuropathic pain and no sensory nerve action potential derivation of the index finger. Therapeutic effects were assessed by physical examination, visual analog scale for pain, and nerve conduction study. Postoperatively, early neuropathic pain relief and good functional recovery were obtained with no PRP-related adverse events. This case report demonstrates the therapeutic potential of intraoperative PRP to enhance the healing process of nerve crush injury in the acute phase and to decrease the neuropathic pain, thus enhancing healing of peripheral nerve crush injury.