Comparison of human papillomavirus DNA tests, liquid-based cytology and conventional cytology for the early detection of cervix uteri cancer.
Comparison of human papillomavirus DNA tests, liquid-based cytology and conventional cytology for the early detection of cervix uteri cancer.
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人乳头瘤病毒 DNA 检测、液基细胞学和常规细胞学在宫颈癌早期检测中的比较。
DOI：
10.1097/01.cej.0000220630.08352.7a
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Figueiredo,Valeska
中科院分区：
文献类型：
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作者：
Girianelli,VaniaR;Thuler,LuizClaudioS;Szklo,Moyses;Donato,Alexandre;Zardo,LuciliaMG;Lozana,JoseA;AlmeidaNeto,OlimpioF;Carvalho,AureniceCL;Matos,JorgeH;Figueiredo,Valeska
比较人乳头瘤病毒DNA检测（由医疗保健专业人员采集和自行采集的样本）和液基细胞学检查与传统细胞学检查在宫颈癌及其前驱病变检测中的性能。对生活在巴西里约热内卢州贫困社区的1777名妇女进行了一项横断面研究。合格标准包括年龄25-59岁，在研究前至少3年内没有进行过巴氏试验。使用单次访视中采集的样本进行细胞学（常规或液基）和人乳头瘤病毒DNA（由医疗保健专业人员采集或自行采集）检测。在至少一项测试中有异常的妇女和70名测试结果为阴性的妇女的系统样本被称为阴道镜检查。检测读数为双盲，关注的结局为高度鳞状上皮内病变或更差。病理报告被用作金标准。高度鳞状上皮内病变或更严重的患病率为2.0%。由卫生专业人员单独或结合常规细胞学收集的人乳头瘤病毒DNA检测具有最高的灵敏度（分别为91.4%和97.1%）。最高的特异性被发现为常规细胞学（91.6%）和由医疗保健专业人员收集的人乳头瘤病毒DNA检测（90.2%）。仅根据检测性能，似乎建议单独或结合细胞学检查使用人乳头瘤病毒DNA检测。但是，在全民中实施这一战略的条件是进行成本效益分析。
To compare the performance of human papillomavirus DNA tests (samples collected by a healthcare professional and self-collected) and liquid-based cytology with conventional cytology in the detection of cervix uteri cancer and its precursor lesions. A cross-sectional study was carried out in 1777 women living in poor communities in Rio de Janeiro State, Brazil. Eligibility criteria included ages 25–59 years and not having had a Papanicolau test within at least 3 years prior to the study. Cytology (conventional or liquid-based) and human papillomavirus DNA (collected by a healthcare professional or self-collected) tests were performed using samples collected in a single visit. Women with abnormalities in at least one test and a systematic sample of 70 women with negative test results were referred to a colposcopic examination. Test readings were double-masked, and the outcome of interest was high-grade squamous intraepithelial lesion or worse. The pathology report was used as the gold standard. The prevalence of high-grade squamous intraepithelial lesion or worse was 2.0%. Human papillomavirus DNA test collected by a health professional alone or combined with conventional cytology had the highest sensitivity (91.4 and 97.1%, respectively). The highest specificity was found for conventional cytology (91.6%) and for a human papillomavirus DNA test collected by a healthcare professional (90.2%). On the basis of only test performance, the use of human papillomavirus DNA tests, alone or combined with cytology, would seem to be recommended. Its population-wide implementation, however, is conditional on a cost-effectiveness analysis.